The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases

Overview

Journal Rev Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Dec 2

PMID 39618876

Authors

Peng Shen

Yue Qiu

Yan-Yan Sun

Yue-Ying Jiang

Xiu-Mei Guan

Min Cheng

Yan-Xia Wang

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are nanoscale vesicles released by cells, which play an important role in intercellular communication by transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release of EVs from cells and tissues, such as endothelial cells, skeletal muscle and adipose tissue, hepatocytes, immune cells, and neuronal cells. Exercise-induced EVs exert cardiovascular protective effects such as anti-inflammatory and anti-oxidative by altering their contents. This paper reviews the cell and tissue sources of EVs induced by exercise of different intensities, the regulatory effects of different exercise intensities on EVs, and their mechanisms of action in cardiovascular diseases. The aim is to provide new insights for the treatment of cardiovascular diseases and offer scientific evidence for the construction of engineered EVs mimicking the effects of exercise.

References

Xhuti D, Nilsson M, Manta K, Tarnopolsky M, Nederveen J . Circulating exosome-like vesicle and skeletal muscle microRNAs are altered with age and resistance training. J Physiol. 2023; 601(22):5051-5073. DOI: 10.1113/JP282663. View

Robbins J, Gerszten R . Exercise, exerkines, and cardiometabolic health: from individual players to a team sport. J Clin Invest. 2023; 133(11). PMC: 10231996. DOI: 10.1172/JCI168121. View

Karvinen S, Korhonen T, Sievanen T, Karppinen J, Juppi H, Jakoaho V . Extracellular vesicles and high-density lipoproteins: Exercise and oestrogen-responsive small RNA carriers. J Extracell Vesicles. 2023; 12(2):e12308. PMC: 9899444. DOI: 10.1002/jev2.12308. View

Sha R, Zhang B, Han X, Peng J, Zheng C, Zhang F . Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway. Med Sci Monit. 2019; 25:4723-4733. PMC: 6607941. DOI: 10.12659/MSM.917213. View

Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N . Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 2009; 55(11):1944-9. DOI: 10.1373/clinchem.2009.125310. View

Fruhbeis C, Helmig S, Tug S, Simon P, Kramer-Albers E . Physical exercise induces rapid release of small extracellular vesicles into the circulation. J Extracell Vesicles. 2015; 4:28239. PMC: 4491306. DOI: 10.3402/jev.v4.28239. View

Chung J, Kim K, Yu N, An S, Lee S, Kwon K . Fluid Shear Stress Regulates the Landscape of microRNAs in Endothelial Cell-Derived Small Extracellular Vesicles and Modulates the Function of Endothelial Cells. Int J Mol Sci. 2022; 23(3). PMC: 8836123. DOI: 10.3390/ijms23031314. View

Yilmaz Y, Kurt R, Yonal O, Polat N, Ataizi Celikel C, Gurdal A . Coronary flow reserve is impaired in patients with nonalcoholic fatty liver disease: association with liver fibrosis. Atherosclerosis. 2010; 211(1):182-6. DOI: 10.1016/j.atherosclerosis.2010.01.049. View

Dresselhaus E, Harris K, Blanchette C, Koles K, Del Signore S, Pescosolido M . ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles. J Cell Biol. 2024; 223(9). PMC: 11157088. DOI: 10.1083/jcb.202405025. View

10.

DSouza R, Woodhead J, Zeng N, Blenkiron C, Merry T, Cameron-Smith D . Circulatory exosomal miRNA following intense exercise is unrelated to muscle and plasma miRNA abundances. Am J Physiol Endocrinol Metab. 2018; 315(4):E723-E733. DOI: 10.1152/ajpendo.00138.2018. View

11.

Wang Y, Chen L, Liu M . Microvesicles and diabetic complications--novel mediators, potential biomarkers and therapeutic targets. Acta Pharmacol Sin. 2014; 35(4):433-43. PMC: 4813723. DOI: 10.1038/aps.2013.188. View

12.

Guescini M, Canonico B, Lucertini F, Maggio S, Annibalini G, Barbieri E . Muscle Releases Alpha-Sarcoglycan Positive Extracellular Vesicles Carrying miRNAs in the Bloodstream. PLoS One. 2015; 10(5):e0125094. PMC: 4425492. DOI: 10.1371/journal.pone.0125094. View

13.

Harraz M, Eacker S, Wang X, Dawson T, Dawson V . MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A. 2012; 109(46):18962-7. PMC: 3503176. DOI: 10.1073/pnas.1121288109. View

14.

Sahoo S, Adamiak M, Mathiyalagan P, Kenneweg F, Kafert-Kasting S, Thum T . Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases: Roadmap to the Clinic. Circulation. 2021; 143(14):1426-1449. PMC: 8021236. DOI: 10.1161/CIRCULATIONAHA.120.049254. View

15.

Di W, Amdanee N, Zhang W, Zhou Y . Long-term exercise-secreted extracellular vesicles promote browning of white adipocytes by suppressing miR-191a-5p. Life Sci. 2020; 263:118464. DOI: 10.1016/j.lfs.2020.118464. View

16.

Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Strassburger K, De Filippo E . Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Sci Adv. 2021; 7(41):eabi9551. PMC: 8500512. DOI: 10.1126/sciadv.abi9551. View

17.

Chen S, Sigdel S, Sawant H, Bihl J, Wang J . Exercise-Intervened Endothelial Progenitor Cell Exosomes Protect N2a Cells by Improving Mitochondrial Function. Int J Mol Sci. 2024; 25(2). PMC: 10816803. DOI: 10.3390/ijms25021148. View

18.

Zhang Q, Higginbotham J, Jeppesen D, Yang Y, Li W, McKinley E . Transfer of Functional Cargo in Exomeres. Cell Rep. 2019; 27(3):940-954.e6. PMC: 6559347. DOI: 10.1016/j.celrep.2019.01.009. View

19.

Medina-Leyte D, Zepeda-Garcia O, Dominguez-Perez M, Gonzalez-Garrido A, Villarreal-Molina T, Jacobo-Albavera L . Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches. Int J Mol Sci. 2021; 22(8). PMC: 8068178. DOI: 10.3390/ijms22083850. View

20.

Alehossein P, Taheri M, Ghahremani P, Dakhlallah D, Brown C, Ishrat T . Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke. Transl Stroke Res. 2022; 14(2):211-237. DOI: 10.1007/s12975-022-01025-4. View