» Articles » PMID: 39618836

Application of a TB Care Cascade to a Novel Household Contact Intervention in Rural South Africa

Overview
Date 2024 Dec 2
PMID 39618836
Authors
Affiliations
Soon will be listed here.
Abstract

Four clinics implemented an intervention to increase TB household contact identification and evaluation in rural Eastern Cape, South Africa. We applied a care cascade framework to assess gaps in evaluation and treatment initiation from April 2021 to June 2023. We identified 1,698 contacts of 287 individuals with TB. The majority of contacts (71%) were screened; 9% of those with symptoms were fully evaluated, and of these, 14% were diagnosed with active TB. This intervention substantially increased TB contact identification and evaluation compared to prior efforts in the same area; however, additional barriers limited the ability to identify and treat secondary cases.

References
1.
Subbaraman R, Nathavitharana R, Mayer K, Satyanarayana S, Chadha V, Arinaminpathy N . Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care. PLoS Med. 2019; 16(2):e1002754. PMC: 6392267. DOI: 10.1371/journal.pmed.1002754. View

2.
Moyo S, Verver S, Mahomed H, Hawkridge A, Kibel M, Hatherill M . Age-related tuberculosis incidence and severity in children under 5 years of age in Cape Town, South Africa. Int J Tuberc Lung Dis. 2010; 14(2):149-54. View

3.
Morrison J, Pai M, Hopewell P . Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis. 2008; 8(6):359-68. DOI: 10.1016/S1473-3099(08)70071-9. View

4.
Myburgh H, Baloyi D, Loveday M, Meehan S, Osman M, Wademan D . A scoping review of patient-centred tuberculosis care interventions: Gaps and opportunities. PLOS Glob Public Health. 2023; 3(2):e0001357. PMC: 10021744. DOI: 10.1371/journal.pgph.0001357. View

5.
Fenta M, Ogundijo O, Warsame A, Belay A . Facilitators and barriers to tuberculosis active case findings in low- and middle-income countries: a systematic review of qualitative research. BMC Infect Dis. 2023; 23(1):515. PMC: 10405492. DOI: 10.1186/s12879-023-08502-7. View