» Articles » PMID: 39618600

Fibrillary Glomerulonephritis Associated With Hashimoto's Thyroiditis

Overview
Journal Cureus
Date 2024 Dec 2
PMID 39618600
Authors
Affiliations
Soon will be listed here.
Abstract

Fibrillary glomerulonephritis is a rare glomerular disease with some correlations between this condition alongside viral infections, malignancy, and autoimmune pathologies. However, the question regarding the pathogenesis is whether patients who develop fibrillary glomerulonephritis do so irrespective of these other pathologies or whether such pathologies induce fibrillary glomerulonephritis through an unknown mechanism. As such, attempts have been made to create associations with this disease to demonstrate further understanding. Here, we would like to present a very rare case of a patient with Hashimoto's thyroiditis associated with fibrillary glomerulonephritis and how such a diagnosis was made. Although autoimmune associations have been made alongside fibrillary glomerulonephritis, this case demonstrates one of the first cases of a patient with fibrillary glomerulonephritis and Hashimoto's thyroiditis. A discussion regarding the treatment and management of our patient, as well as the pathogenesis of this disease, will also be included.

References
1.
Hogan J, Restivo M, Canetta P, Herlitz L, Radhakrishnan J, Appel G . Rituximab treatment for fibrillary glomerulonephritis. Nephrol Dial Transplant. 2014; 29(10):1925-31. DOI: 10.1093/ndt/gfu189. View

2.
Alpers C, Rennke H, HOPPER Jr J, BIAVA C . Fibrillary glomerulonephritis: an entity with unusual immunofluorescence features. Kidney Int. 1987; 31(3):781-9. DOI: 10.1038/ki.1987.66. View

3.
Bridoux F, Hugue V, Coldefy O, Goujon J, Bauwens M, Sechet A . Fibrillary glomerulonephritis and immunotactoid (microtubular) glomerulopathy are associated with distinct immunologic features. Kidney Int. 2002; 62(5):1764-75. DOI: 10.1046/j.1523-1755.2002.00628.x. View

4.
Nasr S, Vrana J, Dasari S, Bridoux F, Fidler M, Kaaki S . DNAJB9 Is a Specific Immunohistochemical Marker for Fibrillary Glomerulonephritis. Kidney Int Rep. 2018; 3(1):56-64. PMC: 5762944. DOI: 10.1016/j.ekir.2017.07.017. View

5.
Javaugue V, Karras A, Glowacki F, McGregor B, Lacombe C, Goujon J . Long-term kidney disease outcomes in fibrillary glomerulonephritis: a case series of 27 patients. Am J Kidney Dis. 2013; 62(4):679-90. DOI: 10.1053/j.ajkd.2013.03.031. View