Plasma Exosomes from Patients with Coronary Artery Disease Promote Atherosclerosis Via Impairing Vascular Endothelial Junctions

Overview

Journal Sci Rep

Specialty Science

Date 2024 Nov 30

PMID 39616226

Authors

Jian Han

Xiaoyan Kang

Yazhen Su

Jing Wang

Xiaogang Cui

Yunfei Bian

Changxin Wu

Affiliations

Soon will be listed here.

Abstract

The underlying mechanism of vascular endothelial hyperpermeability caused by decrease of endothelial junctions occurring in atherosclerosis remains elusive. Our findings identified that plasma exosomes from patients with stable coronary artery disease (Exo) contain differentially expressed miRNAs that are clustered with genes related to cell junctions, prompting us to investigate the role of Exo in regulating vascular endothelial junctions and to elucidate the underlying mechanisms. Here, we show that Exo markedly impair vascular endothelial junctions via suppressing VE-Cadherin and ZO-1 in endothelial cells in vitro and in vivo, consequently increases endothelial permeability. Critically, exosomal miR-140-3p plays a crucial role in Exo-induced inhibition of ZO-1, and may be an important causative factor in the development of endothelial hyperpermeability during atherosclerosis. Additionally, exosomal miR-140-3p level coordinates with severity of SCAD. Targeting miR-140-3p in circulating exosomes might open novel options for treatment of atherosclerosis.

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