» Articles » PMID: 39616168

Structural and Molecular Basis of the Epistasis Effect in Enhanced Affinity Between SARS-CoV-2 KP.3 and ACE2

Overview
Journal Cell Discov
Date 2024 Nov 30
PMID 39616168
Authors
Affiliations
Soon will be listed here.
Citing Articles

Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling of the SARS-CoV-2 Spike Complexes with Antibodies.

Alshahrani M, Parikh V, Foley B, Raisinghani N, Verkhivker G Biomolecules. 2025; 15(2).

PMID: 40001552 PMC: 11853647. DOI: 10.3390/biom15020249.


Structural Immunology of SARS-CoV-2.

Yuan M, Wilson I Immunol Rev. 2024; 329(1):e13431.

PMID: 39731211 PMC: 11727448. DOI: 10.1111/imr.13431.


Structural and Functional Insights into the Evolution of SARS-CoV-2 KP.3.1.1 Spike Protein.

Feng Z, Huang J, Baboo S, Diedrich J, Bangaru S, Paulson J bioRxiv. 2024; .

PMID: 39713475 PMC: 11661143. DOI: 10.1101/2024.12.10.627775.

References
1.
Cao Y, Jian F, Yu Y, Song W, Yisimayi A, Wang J . Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature. 2022; 614(7948):521-529. PMC: 9931576. DOI: 10.1038/s41586-022-05644-7. View

2.
Starr T, Greaney A, Hannon W, Loes A, Hauser K, Dillen J . Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution. Science. 2022; 377(6604):420-424. PMC: 9273037. DOI: 10.1126/science.abo7896. View

3.
Taylor A, Starr T . Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variant. Virus Evol. 2024; 10(1):veae067. PMC: 11414647. DOI: 10.1093/ve/veae067. View

4.
Ma W, Fu H, Jian F, Cao Y, Li M . Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution. Nat Ecol Evol. 2023; 7(9):1457-1466. DOI: 10.1038/s41559-023-02123-8. View

5.
Kaku Y, Uriu K, Okumura K, Ito J, Sato K . Virological characteristics of the SARS-CoV-2 KP.3.1.1 variant. Lancet Infect Dis. 2024; 24(10):e609. DOI: 10.1016/S1473-3099(24)00505-X. View