Bone Mineral Changes in Primary Hyperparathyroidism

Overview

Journal Skeletal Radiol

Specialties Orthopedics
Radiology

Date 1986 Jan 1

PMID 3961529

Citations 3

Authors

M L Richardson

A S Kanter

F O KOLB

B Ettinger

H K Genant

Affiliations

Soon will be listed here.

Abstract

We studied 34 patients with primary hyperparathyroidism in order to assess their bone mineral status, to determine its relationship to biochemical parameters (serum calcium and parathyroid hormone) and surgical status, and to determine the relationship between peripheral cortical bone and spinal trabecular bone in this disease. These patients were studied with radiogrammetry of the metacarpals, Norland-Cameron photon absorptiometry of the radius, quantitative computed tomography (QCT) of the spine, industrial radiography of the hands, and conventional radiography of the thoracolumbar spine. We also calculated a spinal fracture index from thoracolumbar spine films. We found that the appendicular measurements correlated well together, but less well with spinal QCT. The spinal fracture index correlated best with QCT (r = -0.55), although significant dispersion was noted. We found that, in general, these hyperparathyroid patients had statistically significant decrements in bone mineral content in both the appendicular and the axial portions of the skeleton. However, the decrement in the appendicular skeleton did not correlate well with that in the axial skeleton. Therefore we conclude that it is necessary to measure both peripheral and central bone mineral content in order to reliably assess the skeletal demineralizing effects of primary hyperparathyroidism in an individual patient.

Citing Articles

Recovery of bone mineral density in 126 patients after surgery for primary hyperparathyroidism.

Nordenstrom E, Westerdahl J, Bergenfelz A World J Surg. 2004; 28(5):502-7.

PMID: 15085393 DOI: 10.1007/s00268-004-7274-y.

Bone mineral density and circulating cytokines in patients with acromegaly.

Longobardi S, Di Somma C, Di Rella F, Angelillo N, Ferone D, Colao A J Endocrinol Invest. 1998; 21(10):688-93.

PMID: 9854685 DOI: 10.1007/BF03350799.

The influence of surgery on the risk of death in patients with primary hyperparathyroidism.

Hedback G, Oden A, Tisell L World J Surg. 1991; 15(3):399-405; discussion 406-7.

PMID: 1853620 DOI: 10.1007/BF01658740.

References

FEIST J . The biologic basis of radiologic findings in bone disease. Recognition and interpretation of abnormal bone architecture. Radiol Clin North Am. 1970; 8(2):183-206. View

Gallagher J, Nordin B . Treatment with with oestrogens of primary hyperparathyroidism in post-menopausal women. Lancet. 1972; 1(7749):503-7. DOI: 10.1016/s0140-6736(72)90173-0. View

Hahn T, Boisseau V, Avioli L . Effect of chronic corticosteroid administration on diaphyseal and metaphyseal bone mass. J Clin Endocrinol Metab. 1974; 39(2):274-82. DOI: 10.1210/jcem-39-2-274. View

Latorzeff S, Durroux R, Gayrard M, Carles P, DeBrock J . [Quantitative bone biopsy and primary hyperparathyroidism, its role in diagnosis. Apropos of 45 cases]. Rev Rhum Mal Osteoartic. 1976; 43(7-9):497-502. View

Gallagher J, Melton L, Riggs B . Examination of prevalence rates of possible risk factors in a population with a fracture of the proximal femur. Clin Orthop Relat Res. 1980; (153):158-65. View

Dauphine R, Riggs B, SCHOLZ D . Back pain and vertebral crush fractures: an unemphasized mode of presentation for primary hyperparathyroidism. Ann Intern Med. 1975; 83(3):365-7. DOI: 10.7326/0003-4819-83-3-365. View

Parfitt A . The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part III of IV parts; PTH and osteoblasts, the relationship between bone turnover and bone loss, and the state of.... Metabolism. 1976; 25(9):1033-69. DOI: 10.1016/0026-0495(76)90133-5. View

LAFFERTY F . Primary hyperparathyroidism. Changing clinical spectrum, prevalence of hypertension, and discriminant analysis of laboratory tests. Arch Intern Med. 1981; 141(13):1761-6. DOI: 10.1001/archinte.141.13.1761. View

Weiss A . Incidence of subperiosteal resorption in hyperparathyroidism studied by fine detail bone radiography. Clin Radiol. 1974; 25(2):273-6. DOI: 10.1016/s0009-9260(74)80072-3. View

10.

Schlenker R, OLTMAN B, Kotek T . Proceedings: Bone mineral mass and width in normal white women and men. AJR Am J Roentgenol. 1976; 126(6):1282-3. DOI: 10.2214/ajr.126.6.1282. View

11.

Marcus R, Madvig P, CRIM M, Pont A, Kosek J . Conjugated estrogens in the treatment of postmenopausal women with hyperparathyroidism. Ann Intern Med. 1984; 100(5):633-40. DOI: 10.7326/0003-4819-100-5-633. View

12.

Pak C, Stewart A, Kaplan R, Bone H, Notz C, Browne R . Photon absorptiometric analysis of bone density in primary hyperparathyroidism. Lancet. 1975; 2(7923):7-8. DOI: 10.1016/s0140-6736(75)92950-5. View

13.

Elsasser U, Reeve J . Bone density measurement with computed tomography. Br Med Bull. 1980; 36(3):293-6. DOI: 10.1093/oxfordjournals.bmb.a071656. View

14.

. Osteoporosis: Part II. Prevention of Bone Loss and Fractures in Women and Risks of Menopausal Estrogen Therapy. West J Med. 1983; 139(2):204-11. PMC: 1010931. View

15.

PUGH D . Subperiosteal resorption of bone; a roentgenologic manifestation of primary hyperparathyroidism and renal osteodystrophy. Am J Roentgenol Radium Ther. 1951; 66(4):577-86. View

16.

Hossain M, Smith D, Nordin B . Parathyroid activity and postmenopausal osteoporosis. Lancet. 1970; 1(7651):809-11. DOI: 10.1016/s0140-6736(70)92410-4. View

17.

Broadus A, Magee J, Mallette L, Horst R, Lang R, Jensen P . A detailed evaluation of oral phosphate therapy in selected patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 1983; 56(5):953-61. DOI: 10.1210/jcem-56-5-953. View

18.

Garn S, POZNANSKI A, Nagy J . Bone measurement in the differential diagnosis of osteopenia and osteoporosis. Radiology. 1971; 100(3):509-18. DOI: 10.1148/100.3.509. View

19.

Ruegsegger P, Elsasser U, Anliker M, GNEHM H, KIND H, PRADER A . Quantification of bone mineralization using computed tomography. Radiology. 1976; 121(1):93-7. DOI: 10.1148/121.1.93. View

20.

. Osteoporosis. Part I. Advanced radiologic assessment using quantitative computed tomography. West J Med. 1983; 139(1):75-84. PMC: 1010880. View