Recent Novelties in Research and Management of Cerebrospinal Cavernous Malformations

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 2024 Nov 29

PMID 39613863

Authors

Laurel Rauschenbach

Philipp Dammann

Ulrich Sure

Affiliations

Soon will be listed here.

Abstract

In recent years, knowledge about cerebrospinal cavernomas has grown considerably, leading to the development of initial guidelines and treatment recommendations. However, due to the rarity and heterogeneity of the disease, the level of evidence remains limited, leaving many questions unanswered and subject to ongoing debate. Therefore, an up-to-date review of this field's latest developments and controversies is reasonable.

References

Salman R, Hall J, Horne M, Moultrie F, Josephson C, Bhattacharya J . Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study. Lancet Neurol. 2012; 11(3):217-24. PMC: 3282211. DOI: 10.1016/S1474-4422(12)70004-2. View

La Rocca G, Ius T, Mazzucchi E, Simboli G, Altieri R, Garbossa D . Trans-sulcal versus trans-parenchymal approach in supratentorial cavernomas. A multicentric experience. Clin Neurol Neurosurg. 2020; 197:106180. DOI: 10.1016/j.clineuro.2020.106180. View

Awad I, Robinson Jr J, Mohanty S, Estes M . Mixed vascular malformations of the brain: clinical and pathogenetic considerations. Neurosurgery. 1993; 33(2):179-88; discussion 188. DOI: 10.1227/00006123-199308000-00001. View

Poorthuis M, Samarasekera N, Kontoh K, Stuart I, Cope B, Kitchen N . Comparative studies of the diagnosis and treatment of cerebral cavernous malformations in adults: systematic review. Acta Neurochir (Wien). 2013; 155(4):643-9. DOI: 10.1007/s00701-013-1621-4. View

Zanello M, Meyer B, Still M, Goodden J, Colle H, Schichor C . Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers. Seizure. 2019; 69:31-40. DOI: 10.1016/j.seizure.2019.03.022. View

Sevy A, Gavaret M, Trebuchon A, Vaugier L, Wendling F, Carron R . Beyond the lesion: the epileptogenic networks around cavernous angiomas. Epilepsy Res. 2014; 108(4):701-8. DOI: 10.1016/j.eplepsyres.2014.02.018. View

Dammann P, Herten A, Santos A, Rauschenbach L, Chen B, Oppong M . Multimodal outcome assessment after surgery for brainstem cavernous malformations. J Neurosurg. 2020; 135(2):401-409. DOI: 10.3171/2020.6.JNS201823. View

Cohen D, Zubay G, Goodman R . Seizure outcome after lesionectomy for cavernous malformations. J Neurosurg. 1995; 83(2):237-42. DOI: 10.3171/jns.1995.83.2.0237. View

Denier C, Labauge P, Bergametti F, Marchelli F, Riant F, Arnoult M . Genotype-phenotype correlations in cerebral cavernous malformations patients. Ann Neurol. 2006; 60(5):550-556. DOI: 10.1002/ana.20947. View

10.

Poorthuis M, Rinkel L, Lammy S, Salman R . Stereotactic radiosurgery for cerebral cavernous malformations: A systematic review. Neurology. 2019; 93(21):e1971-e1979. DOI: 10.1212/WNL.0000000000008521. View

11.

Tasiou A, Brotis A, Kalogeras A, Tzerefos C, Alleyne Jr C, Andreou A . Cavernous malformations of the central nervous system: An international consensus statement. Brain Spine. 2023; 3:102707. PMC: 10668094. DOI: 10.1016/j.bas.2023.102707. View

12.

Chen B, Lahl K, Saban D, Lenkeit A, Rauschenbach L, Santos A . Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations. Front Neurol. 2023; 13:1010170. PMC: 9847255. DOI: 10.3389/fneur.2022.1010170. View

13.

Shoubash L, Baldauf J, Matthes M, Kirsch M, Rath M, Felbor U . Long-term outcome and quality of life after CNS cavernoma resection: eloquent vs. non-eloquent areas. Neurosurg Rev. 2021; 45(1):649-660. PMC: 8827309. DOI: 10.1007/s10143-021-01572-8. View

14.

Ayata C, Kim H, Morrison L, Liao J, Gutierrez J, Lopez-Toledano M . Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations. Neurol Genet. 2024; 10(1):e200121. PMC: 10766084. DOI: 10.1212/NXG.0000000000200121. View

15.

Horne M, Flemming K, Su I, Stapf C, Jeon J, Li D . Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data. Lancet Neurol. 2015; 15(2):166-173. PMC: 4710581. DOI: 10.1016/S1474-4422(15)00303-8. View

16.

Englot D, Han S, Lawton M, Chang E . Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations. J Neurosurg. 2011; 115(6):1169-74. DOI: 10.3171/2011.7.JNS11536. View

17.

Dammann P, Wrede K, Jabbarli R, Neuschulte S, Menzler K, Zhu Y . Outcome after conservative management or surgical treatment for new-onset epilepsy in cerebral cavernous malformation. J Neurosurg. 2016; 126(4):1303-1311. DOI: 10.3171/2016.4.JNS1661. View

18.

Kearns K, Chen C, Tvrdik P, Park M, Kalani M . Outcomes of Surgery for Brainstem Cavernous Malformations: A Systematic Review. Stroke. 2019; 50(10):2964-2966. DOI: 10.1161/STROKEAHA.119.026120. View

19.

Srinath A, Xie B, Li Y, Sone J, Romanos S, Chen C . Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023; 3(1):35. PMC: 9984539. DOI: 10.1038/s43856-023-00265-1. View

20.

Santos A, Rauschenbach L, Riess C, Georgiades I, Ficilar B, Gallardo E . Outcome after conservative or surgical treatment for new-onset epilepsy in children with cerebral cavernous malformation. Seizure. 2023; 111:23-29. DOI: 10.1016/j.seizure.2023.07.011. View