Clinical Vignettes Illustrating the Spectrum of Hepatocellular Carcinoma Presentation and Treatment

Hepatocellular carcinoma (HCC) presentation reflects a complex interaction between cancer stage, severity of liver disease, and overall functional status. This article provides clinical vignettes that illustrate these complex interactions and how a multidisciplinary approach can result in rational, evidence-based plans of care that factor in the local standard of care as well as patient preference. The vignettes range from a patient with early stage HCC and good liver function to a patient with metastatic disease. The full spectrum of treatments that can be applied ranging from curative surgery and transplantation to locoregional therapy and systemic therapy are shown.