Crotonylation Modification and Its Role in Diseases

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2024 Nov 28

PMID 39606030

Authors

Yi Guo

Junqin Li

Kaiming Zhang

Affiliations

Soon will be listed here.

Abstract

Protein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades. Crotonylation is conserved and is regulated by a series of enzymes including "writer", "eraser", and "reader". In recent years, crotonylation has received extensive attention due to its breakthrough progress in reproduction, development and pathogenesis of diseases. Here we brief the crotonylation-related enzyme systems, biological functions, and diseases caused by abnormal crotonylation, which provide new ideas for developing disease intervention and treatment regimens.

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