Effect of the Intake of Solid Block Dairy Products Like Cheese on Serum Uric Acid in Children: A Preliminary Mechanistic Investigation

Overview

Journal Nutrients

Date 2024 Nov 27

PMID 39599650

Authors

Zhongting Lu

Zhenchuang Tang

Xin Guo

Lei Liu

Xuemei Cheng

Lianlong Yu

Guangyan Cheng

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to investigate the relationship between the intake of solid block dairy products like cheese and serum uric acid levels, along with its potential physiological mechanisms.

Methods: Data for our study were obtained from the Chinese Children and Lactating Women Nutrition and Health Surveillance. Generalized linear models and restricted cubic splines were employed to analyze the relationship between the intake of solid block dairy products like cheese and serum uric acid levels. Two-sample Mendelian randomization (TSMR) analysis was conducted to infer causality, based on a large sample size and robust methodology. Gene Ontology (GO) enrichment analysis was also performed to identify potential biological pathways.

Results: Among all types of dairy products, a significant negative association with serum uric acid levels was observed only for the intake of solid block dairy products like cheese, regardless of covariate adjustment (β = -0.182, < 0.001). TSMR results supported a negative causal relationship between cheese intake and serum uric acid levels (β = -0.103, 95% CI: -0.149 to -0.057; = 0.002). The JAK-STAT signaling pathway and autophagy regulation were identified as potential physiological mechanisms underlying this relationship.

Conclusions: The intake of solid block dairy products like cheese was found to result in decreased levels of serum uric acid, with potential mechanisms involving the JAK-STAT signaling pathway and the regulation of autophagy.

References

Dehlin M, Jacobsson L, Roddy E . Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020; 16(7):380-390. DOI: 10.1038/s41584-020-0441-1. View

Haug A, Hostmark A, Harstad O . Bovine milk in human nutrition--a review. Lipids Health Dis. 2007; 6:25. PMC: 2039733. DOI: 10.1186/1476-511X-6-25. View

Dalbeth N, Palmano K . Effects of dairy intake on hyperuricemia and gout. Curr Rheumatol Rep. 2010; 13(2):132-7. DOI: 10.1007/s11926-010-0160-8. View

Banerjee S, Biehl A, Gadina M, Hasni S, Schwartz D . JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects. Drugs. 2017; 77(5):521-546. PMC: 7102286. DOI: 10.1007/s40265-017-0701-9. View

Yamanaka H . Gout and hyperuricemia in young people. Curr Opin Rheumatol. 2010; 23(2):156-60. DOI: 10.1097/BOR.0b013e3283432d35. View

Mena-Sanchez G, Babio N, Becerra-Tomas N, Martinez-Gonzalez M, Diaz-Lopez A, Corella D . Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome. Nutr Metab Cardiovasc Dis. 2019; 30(2):214-222. DOI: 10.1016/j.numecd.2019.09.023. View

Biasizzo M, Kopitar-Jerala N . Interplay Between NLRP3 Inflammasome and Autophagy. Front Immunol. 2020; 11:591803. PMC: 7583715. DOI: 10.3389/fimmu.2020.591803. View

Zhang M, Dong X, Huang Z, Li X, Zhao Y, Wang Y . Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies. Adv Nutr. 2023; 14(5):1170-1186. PMC: 10509445. DOI: 10.1016/j.advnut.2023.06.007. View

Wang R, Halimulati M, Huang X, Ma Y, Li L, Zhang Z . Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia. J Adv Res. 2022; 52:19-28. PMC: 10555773. DOI: 10.1016/j.jare.2022.11.003. View

10.

Hu Y, Shi Y, Chen H, Tao M, Zhou X, Li J . Blockade of Autophagy Prevents the Progression of Hyperuricemic Nephropathy Through Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis. Front Immunol. 2022; 13:858494. PMC: 8924517. DOI: 10.3389/fimmu.2022.858494. View

11.

Li F, Yang W, Sun S, He W, Xu S, Han B . Dietary factors and hypertension: A Mendelian randomization analysis. Food Sci Nutr. 2024; 12(4):2502-2510. PMC: 11016398. DOI: 10.1002/fsn3.3931. View

12.

Tang C, Livingston M, Liu Z, Dong Z . Autophagy in kidney homeostasis and disease. Nat Rev Nephrol. 2020; 16(9):489-508. PMC: 7868042. DOI: 10.1038/s41581-020-0309-2. View

13.

Gherghina M, Peride I, Tiglis M, Neagu T, Niculae A, Checherita I . Uric Acid and Oxidative Stress-Relationship with Cardiovascular, Metabolic, and Renal Impairment. Int J Mol Sci. 2022; 23(6). PMC: 8949471. DOI: 10.3390/ijms23063188. View

14.

Yanai H, Adachi H, Hakoshima M, Katsuyama H . Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease. Int J Mol Sci. 2021; 22(17). PMC: 8431537. DOI: 10.3390/ijms22179221. View

15.

Li Y, Shen Z, Zhu B, Zhang H, Zhang X, Ding X . Demographic, regional and temporal trends of hyperuricemia epidemics in mainland China from 2000 to 2019: a systematic review and meta-analysis. Glob Health Action. 2021; 14(1):1874652. PMC: 7833047. DOI: 10.1080/16549716.2021.1874652. View

16.

Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q . Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Ther. 2023; 8(1):204. PMC: 10196327. DOI: 10.1038/s41392-023-01468-7. View

17.

El Ridi R, Tallima H . Physiological functions and pathogenic potential of uric acid: A review. J Adv Res. 2017; 8(5):487-493. PMC: 5512149. DOI: 10.1016/j.jare.2017.03.003. View

18.

Wen L, Yang H, Ma L, Fu P . The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy. Mol Cell Biochem. 2021; 476(3):1377-1386. DOI: 10.1007/s11010-020-03997-z. View

19.

Collotta D, Franchina M, Carlucci V, Collino M . Recent advances in JAK inhibitors for the treatment of metabolic syndrome. Front Pharmacol. 2023; 14:1245535. PMC: 10494544. DOI: 10.3389/fphar.2023.1245535. View

20.

Hu Q, Bian Q, Rong D, Wang L, Song J, Huang H . JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens. Front Bioeng Biotechnol. 2023; 11:1110765. PMC: 9995824. DOI: 10.3389/fbioe.2023.1110765. View