Comprehensive Study of Antibiotic Resistance in Spp.: Comparison of Influents and Effluents of Wastewater Treatment Plants

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2024 Nov 27

PMID 39596765

Authors

Ji-Hyun Park

Kyung-Seon Bae

Jihyun Kang

Eung-Roh Park

Jeong-Ki Yoon

Affiliations

Soon will be listed here.

Abstract

: The spread of antibiotic resistance, particularly through spp., in wastewater treatment plants (WWTPs) poses significant public health risks. Given that research on antibiotic-resistant enterococci and their antibiotic-resistance genes in aquatic environments is limited, we evaluated the role of spp. in WWTPs by comparing the antibiotic resistance rates, gene prevalence, biofilm formation, and residual antibiotics in the influent and effluent using culture-based methods. : In 2022, influent and effluent samples were collected from 11 WWTPs in South Korea. Overall, 804 strains were isolated, and their resistance to 16 antibiotics was assessed using the microdilution method. : High resistance to tetracycline, ciprofloxacin, kanamycin, and erythromycin was observed. However, no significant differences in the overall resistance rates and biofilm formation were observed between the influent and effluent. Rates of resistance to ampicillin, ciprofloxacin, and gentamicin, as well as the prevalence of the and genes, increased in the effluent, whereas resistance rates to chloramphenicol, florfenicol, erythromycin, and tylosin tartrate, along with the prevalence of the gene, decreased. , , and were the dominant species, with exhibiting the highest resistance. : Our results suggest that WWTPs do not effectively reduce the rates of resistant spp., indicating the need for continuous monitoring and improvement of the treatment process to mitigate the environmental release of antibiotic-resistant bacteria.

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