Abnormalities of Oocyte Maturation: Mechanisms and Implications

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Nov 27

PMID 39596263

Authors

Giorgio Maria Baldini

Dario Lot

Antonio Malvasi

Antonio Simone Lagana

Antonella Vimercati

Miriam Dellino

Ettore Cicinelli

Domenico Baldini

Giuseppe Trojano

Affiliations

Soon will be listed here.

Abstract

The elucidation of oocyte maturation mechanisms is paramount for advancing embryo development within the scope of assisted reproductive technologies (ART). Both cytoplasmic and nuclear maturation represent intricate processes governed by tightly regulated cellular pathways, which are essential for ensuring the oocyte's competence for fertilization and subsequent embryogenesis. A comprehensive grasp of these mechanisms is vital, as the maturation stage of the oocyte significantly influences chromosomal integrity, spindle formation, and its ability to support the initial stages of embryonic development. By leveraging this knowledge, we can enhance in vitro fertilization (IVF) protocols, refining ovarian stimulation regimens and culture conditions to improve oocyte quality. This, in turn, has the potential to boost pregnancy rates and outcomes. Further research in this area will contribute to the development of novel interventions that aim to increase the efficacy of preimplantation embryonic development, offering new opportunities for individuals undergoing fertility treatments.

Citing Articles

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health.

Moustakli E, Stavros S, Katopodis P, Skentou C, Potiris A, Panagopoulos P Cells. 2025; 14(1.

PMID: 39791737 PMC: 11720220. DOI: 10.3390/cells14010036.

References

Hsueh A, Kawamura K, Cheng Y, Fauser B . Intraovarian control of early folliculogenesis. Endocr Rev. 2014; 36(1):1-24. PMC: 4309737. DOI: 10.1210/er.2014-1020. View

Qi L, Chen X, Wang J, Lv B, Zhang J, Ni B . Mitochondria: the panacea to improve oocyte quality?. Ann Transl Med. 2020; 7(23):789. PMC: 6990045. DOI: 10.21037/atm.2019.12.02. View

Yamada M, Sato S, Ooka R, Akashi K, Nakamura A, Miyado K . Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality. Reprod Med Biol. 2021; 20(1):53-61. PMC: 7812462. DOI: 10.1002/rmb2.12356. View

Jiang Z, Shen H . Mitochondria: emerging therapeutic strategies for oocyte rescue. Reprod Sci. 2021; 29(3):711-722. DOI: 10.1007/s43032-021-00523-4. View

Pasquariello R, Ermisch A, Silva E, McCormick S, Logsdon D, Barfield J . Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†. Biol Reprod. 2018; 100(4):971-981. DOI: 10.1093/biolre/ioy248. View

Wang C, Zhou B, Xia G . Mechanisms controlling germline cyst breakdown and primordial follicle formation. Cell Mol Life Sci. 2017; 74(14):2547-2566. PMC: 11107689. DOI: 10.1007/s00018-017-2480-6. View

Grettka K, Idzik K, Lewandowska K, Swietek K, Palini S, Silvestris F . Ovarian Stem Cells for Women's Infertility: State of the Art. Biomedicines. 2024; 12(6). PMC: 11200641. DOI: 10.3390/biomedicines12061139. View

Lan Y, Zhang S, Gong F, Lu C, Lin G, Hu L . The mitochondrial DNA copy number of cumulus granulosa cells may be related to the maturity of oocyte cytoplasm. Hum Reprod. 2020; 35(5):1120-1129. DOI: 10.1093/humrep/deaa085. View

Guigon C, Cohen-Tannoudji M . [Reconsidering the roles of female germ cells in ovarian development and folliculogenesis]. Biol Aujourdhui. 2012; 205(4):223-33. DOI: 10.1051/jbio/2011022. View

10.

Morimoto Y, Kankanam Gamage U, Yamochi T, Saeki N, Morimoto N, Yamanaka M . Mitochondrial Transfer into Human Oocytes Improved Embryo Quality and Clinical Outcomes in Recurrent Pregnancy Failure Cases. Int J Mol Sci. 2023; 24(3). PMC: 9917531. DOI: 10.3390/ijms24032738. View

11.

Battaglia D, Klein N, Soules M . Changes in centrosomal domains during meiotic maturation in the human oocyte. Mol Hum Reprod. 1996; 2(11):845-51. DOI: 10.1093/molehr/2.11.845. View

12.

Barnes F, Sirard M . Oocyte maturation. Semin Reprod Med. 2001; 18(2):123-31. DOI: 10.1055/s-2000-12551. View

13.

Byskov A, Andersen C, Nordholm L, Thogersen H, Xia G, Wassmann O . Chemical structure of sterols that activate oocyte meiosis. Nature. 1995; 374(6522):559-62. DOI: 10.1038/374559a0. View

14.

Prochazka R, Petlach M, Nagyova E, Nemcova L . Effect of epidermal growth factor-like peptides on pig cumulus cell expansion, oocyte maturation, and acquisition of developmental competence in vitro: comparison with gonadotropins. Reproduction. 2011; 141(4):425-35. DOI: 10.1530/REP-10-0418. View

15.

Tornell J, Billig H, Hillensjo T . Regulation of oocyte maturation by changes in ovarian levels of cyclic nucleotides. Hum Reprod. 1991; 6(3):411-22. DOI: 10.1093/oxfordjournals.humrep.a137351. View

16.

Rodriguez-Varela C, Labarta E . Role of Mitochondria Transfer in Infertility: A Commentary. Cells. 2022; 11(12). PMC: 9221194. DOI: 10.3390/cells11121867. View

17.

Brenner C, Barritt J, Willadsen S, Cohen J . Mitochondrial DNA heteroplasmy after human ooplasmic transplantation. Fertil Steril. 2000; 74(3):573-8. DOI: 10.1016/s0015-0282(00)00681-6. View

18.

Kawano Y, Narahara H, Matsui N, Nasu K, Miyamura K, Miyakawa I . Insulin-like growth factor-binding protein-1 in human follicular fluid: a marker for oocyte maturation. Gynecol Obstet Invest. 1997; 44(3):145-8. DOI: 10.1159/000291507. View

19.

Mobarak H, Heidarpour M, Tsai P, Rezabakhsh A, Rahbarghazi R, Nouri M . Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging. Cell Biosci. 2019; 9:95. PMC: 6884882. DOI: 10.1186/s13578-019-0360-5. View

20.

Zhang Y, Yan Z, Qin Q, Nisenblat V, Chang H, Yu Y . Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. Mol Cell. 2018; 72(6):1021-1034.e4. DOI: 10.1016/j.molcel.2018.10.029. View