The Effect of Overweight/Obesity on Cutaneous Microvascular Reactivity As Measured by Laser-Doppler Fluxmetry: A Systematic Review

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 Nov 27

PMID 39595054

Authors

Ally McIllhatton

Sean Lanting

Vivienne Chuter

Affiliations

Soon will be listed here.

Abstract

Introduction: We sought to determine by systematic review the independent effect of overweight/obesity on cutaneous microvascular reactivity in adults as measured by laser-Doppler fluxmetry.

Methods: CINAHL Complete, SPORTSDiscus, Embase, Medline, and Cochrane Library were searched until March 2024 to identify studies investigating cutaneous microvascular reactivity in an overweight/obese but otherwise healthy group versus a lean/healthy weight. Reporting is consistent with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Quality appraisal of included studies was performed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist.

Results: Nineteen eligible articles reported on 1847 participants. Most articles reported impaired cutaneous microvascular reactivity in cohorts with overweight/obesity compared to cohorts with lean/healthy weight. Investigating reactivity via post-occlusive reactive hyperaemia (PORH) and iontophoresis of acetylcholine (ACh) has shown significance. No significant differences were reported between groups in response to local heating or to iontophoresis of methacholine or insulin, while findings of the effect of obesity on iontophoresis of sodium nitroprusside (SNP) were mixed.

Conclusions: The pathophysiology of impaired cutaneous microvascular reactivity in overweight/obesity requires further investigation; however, impaired function of vasoactive substances, endothelial dysfunction, sensory nerves, and calcium-activated potassium channels may be implicated. Identifying these impaired microvascular responses should inform possible therapy targets in overweight and obesity.activated potassium channels may be implicated. Identifying these impaired microvascular responses should inform possible therapy targets in overweight and obesity.

References

Jonk A, Houben A, Schaper N, de Leeuw P, Serne E, Smulders Y . Obesity is associated with impaired endothelial function in the postprandial state. Microvasc Res. 2011; 82(3):423-9. DOI: 10.1016/j.mvr.2011.08.006. View

Ramke J, Palagyi A, Jordan V, Petkovic J, Gilbert C . Using the STROBE statement to assess reporting in blindness prevalence surveys in low and middle income countries. PLoS One. 2017; 12(5):e0176178. PMC: 5421753. DOI: 10.1371/journal.pone.0176178. View

Ben Nasr H, Dimassi S, Mhadhbi R, Debbabi H, Kortas M, Tabka Z . Functional G894T (rs1799983) polymorphism and intron-4 VNTR variant of nitric oxide synthase (NOS3) gene are susceptibility biomarkers of obesity among Tunisians. Obes Res Clin Pract. 2015; 10(4):465-75. DOI: 10.1016/j.orcp.2015.04.008. View

Farkas G, Gater D . Neurogenic obesity and systemic inflammation following spinal cord injury: A review. J Spinal Cord Med. 2017; 41(4):378-387. PMC: 6055969. DOI: 10.1080/10790268.2017.1357104. View

Jonk A, Houben A, de Jongh R, Serne E, Schaper N, Stehouwer C . Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology (Bethesda). 2007; 22:252-60. DOI: 10.1152/physiol.00012.2007. View

Turner J, Belch J, Khan F . Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis. Trends Cardiovasc Med. 2008; 18(4):109-16. DOI: 10.1016/j.tcm.2008.02.001. View

van der Heijden D, van Leeuwen M, Janssens G, Lenzen M, van de Ven P, Eringa E . Body Mass Index Is Associated With Microvascular Endothelial Dysfunction in Patients With Treated Metabolic Risk Factors and Suspected Coronary Artery Disease. J Am Heart Assoc. 2017; 6(9). PMC: 5634274. DOI: 10.1161/JAHA.117.006082. View

Al-Tahami B, Get Bee Y, Ismail A, Rasool A . Impaired microvascular endothelial function in relatively young obese humans is associated with altered metabolic and inflammatory markers. Clin Hemorheol Microcirc. 2011; 47(2):87-97. DOI: 10.3233/CH-2010-1370. View

Jax T, Stirban A, Terjung A, Esmaeili H, Berk A, Thiemann S . A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes. Cardiovasc Diabetol. 2017; 16(1):13. PMC: 5251248. DOI: 10.1186/s12933-016-0493-3. View

10.

Houben A, Eringa E, Jonk A, Serne E, Smulders Y, Stehouwer C . Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease. Curr Cardiovasc Risk Rep. 2012; 6(1):80-90. PMC: 3251783. DOI: 10.1007/s12170-011-0214-0. View

11.

Ranasinghe C, Gamage P, Katulanda P, Andraweera N, Thilakarathne S, Tharanga P . Relationship between Body Mass Index (BMI) and body fat percentage, estimated by bioelectrical impedance, in a group of Sri Lankan adults: a cross sectional study. BMC Public Health. 2013; 13:797. PMC: 3766672. DOI: 10.1186/1471-2458-13-797. View

12.

Rossi M, Carpi A, Galetta F, Franzoni F, Santoro G . The investigation of skin blood flowmotion: a new approach to study the microcirculatory impairment in vascular diseases?. Biomed Pharmacother. 2006; 60(8):437-42. DOI: 10.1016/j.biopha.2006.07.012. View

13.

McLafferty E, Hendry C, Alistair F . The integumentary system: anatomy, physiology and function of skin. Nurs Stand. 2012; 27(3):35-42. DOI: 10.7748/ns2012.10.27.7.35.c9358. View

14.

Binggeli C, Spieker L, Corti R, Sudano I, Stojanovic V, Hayoz D . Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?. J Am Coll Cardiol. 2003; 42(1):71-7. DOI: 10.1016/s0735-1097(03)00505-9. View

15.

Mokdad A, Ford E, Bowman B, Dietz W, Vinicor F, Bales V . Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2002; 289(1):76-9. DOI: 10.1001/jama.289.1.76. View

16.

Houben A, Martens R, Stehouwer C . Assessing Microvascular Function in Humans from a Chronic Disease Perspective. J Am Soc Nephrol. 2017; 28(12):3461-3472. PMC: 5698072. DOI: 10.1681/ASN.2017020157. View

17.

Roustit M, Blaise S, Millet C, Cracowski J . Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry. Microvasc Res. 2010; 79(2):102-8. DOI: 10.1016/j.mvr.2010.01.001. View

18.

Dimassi S, Chahed K, Boumiza S, Canault M, Tabka Z, Laurant P . Role of eNOS- and NOX-containing microparticles in endothelial dysfunction in patients with obesity. Obesity (Silver Spring). 2016; 24(6):1305-12. DOI: 10.1002/oby.21508. View

19.

Fredriksson I, Larsson M, Stromberg T . Model-based quantitative laser Doppler flowmetry in skin. J Biomed Opt. 2010; 15(5):057002. DOI: 10.1117/1.3484746. View

20.

Cracowski J, Minson C, Salvat-Melis M, Halliwill J . Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci. 2006; 27(9):503-8. DOI: 10.1016/j.tips.2006.07.008. View