Chemical Constituents from the Fruit of and Their Anti-Inflammatory Activity

Overview

Journal Antioxidants (Basel)

Date 2024 Nov 27

PMID 39594480

Authors

Fan Cao

Jing Chen

Zheng-Tao Lin

Han-Ying Lin

Bin Liu

Zhen-Wei Chen

Xin-Hua Ma

Yong-Hong Zhang

Affiliations

Soon will be listed here.

Abstract

Phytochemical investigations of fruits have led to the isolation of a novel tirucallane triterpenoid (), four new limonoids (-), and four known limonoids (-). Their structures were clarified by comprehensive spectroscopic and spectrometric analyses. The anti-inflammatory activities of isolated compounds were assessed in vitro. Compound exhibited the most potent anti-inflammatory effect, with an IC value of 22.04 μM. Additionally, compound attenuated LPS-induced reactive oxygen species (ROS) production and reduced the levels of inflammatory mediators IL-6 and TNF-. A mechanistic study revealed that limonoid suppresses the expression of iNOS and JAK2 and is implicated in the modulation of the NF-κB signaling cascade, which reveals its anti-inflammatory actions.

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