Sensory Processing Subtypes Relate to Distinct Emotional and Behavioral Phenotypes in a Mixed Neurodevelopmental Cohort

Overview

Journal Sci Rep

Specialty Science

Date 2024 Nov 26

PMID 39592662

Authors

Annie Brandes-Aitken

Rachel Powers

Jamie Wren

Robyn Chu

Kevin A Shapiro

Mary Steele

Pratik Mukherjee

Elysa J Marco

Affiliations

Soon will be listed here.

Abstract

Children with autism and other neurodevelopmental concerns (NDC) frequently exhibit an array of sensory processing dysfunction phenotypes, posing a significant challenge their adaptive development. Additionally, these children often encounter difficulties with self-regulation, including emotion dysregulation, anxiety, and symptoms associated with attention and hyperactivity. However, further research is required to comprehend how patterns of sensory processing differences across neurodevelopmental conditions may contribute to regulatory control problems. Adopting a transdiagnostic perspective within the Research Domain Criteria (RDoC) framework, this study examined the relationship between clusters of sensory processing phenotypes and differential patterns of self-regulation behaviors. We recruited a sample of 117 participants (8-12 years) with a diverse range of neurodevelopmental concerns including autism, ADHD, anxiety, and sensory processing differences. This study aimed to (1) establish the prevalence of self-regulation problems in a community-recruited cohort of children with diverse NDCs; (2) construct data-driven sensory processing latent subtypes; (3) investigate group differences in emotion dysregulation, anxiety, and ADHD symptoms. Results showed that 39% of NDC children met clinically concerning thresholds for emotion dysregulation, 19% for anxiety, and 62% for ADHD. Second, latent profile analysis identified five sensory processing subtypes categorized by modality: Typical Processing, Intermediate/Mixed, Sensory Over-Responsive, Sensory Seeking, and Sensory Under-Responsive. Notably, the Sensory Over-Responsive group exhibited distinctively elevated anxiety scores, while the Sensory Seeking and Sensory Under-Responsive groups showed heightened ADHD scores. Intriguingly, the Sensory Over-Responsive, Sensory Under-Responsive, and Sensory Seeking subgroups all demonstrated elevated emotion dysregulation scores, suggesting a potential shared mechanism of emotion dysregulation that might elucidate the connection between sensory processing differences and increased anxiety and ADHD behaviors in children with autism and other NDCs.

References

Jung J, Zbozinek T, Cummings K, Wilhelm F, Dapretto M, Craske M . Associations between physiological and neural measures of sensory reactivity in youth with autism. J Child Psychol Psychiatry. 2021; 62(10):1183-1194. PMC: 9469758. DOI: 10.1111/jcpp.13387. View

Kadlaskar G, Mao P, Iosif A, Amaral D, Nordahl C, Miller M . Patterns of sensory processing in young children with autism: Differences in autism characteristics, adaptive skills, and attentional problems. Autism. 2022; 27(3):723-736. PMC: 9947195. DOI: 10.1177/13623613221115951. View

Simpson K, Adams D, Alston-Knox C, Heussler H, Keen D . Exploring the Sensory Profiles of Children on the Autism Spectrum Using the Short Sensory Profile-2 (SSP-2). J Autism Dev Disord. 2019; 49(5):2069-2079. DOI: 10.1007/s10803-019-03889-2. View

Dajani D, Llabre M, Nebel M, Mostofsky S, Uddin L . Heterogeneity of executive functions among comorbid neurodevelopmental disorders. Sci Rep. 2016; 6:36566. PMC: 5101520. DOI: 10.1038/srep36566. View

Baranek G, David F, Poe M, Stone W, Watson L . Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development. J Child Psychol Psychiatry. 2006; 47(6):591-601. DOI: 10.1111/j.1469-7610.2005.01546.x. View

Cisler J, Olatunji B, Feldner M, Forsyth J . Emotion Regulation and the Anxiety Disorders: An Integrative Review. J Psychopathol Behav Assess. 2010; 32(1):68-82. PMC: 2901125. DOI: 10.1007/s10862-009-9161-1. View

Ausderau K, Furlong M, Sideris J, Bulluck J, Little L, Watson L . Sensory subtypes in children with autism spectrum disorder: latent profile transition analysis using a national survey of sensory features. J Child Psychol Psychiatry. 2014; 55(8):935-44. PMC: 4159682. DOI: 10.1111/jcpp.12219. View

Ghanizadeh A . Sensory processing problems in children with ADHD, a systematic review. Psychiatry Investig. 2011; 8(2):89-94. PMC: 3149116. DOI: 10.4306/pi.2011.8.2.89. View

Little L, Dean E, Tomchek S, Dunn W . Classifying sensory profiles of children in the general population. Child Care Health Dev. 2016; 43(1):81-88. DOI: 10.1111/cch.12391. View

10.

He J, Williams Z, Harris A, Powell H, Schaaf R, Tavassoli T . A working taxonomy for describing the sensory differences of autism. Mol Autism. 2023; 14(1):15. PMC: 10091684. DOI: 10.1186/s13229-022-00534-1. View

11.

Sloan E, Hall K, Moulding R, Bryce S, Mildred H, Staiger P . Emotion regulation as a transdiagnostic treatment construct across anxiety, depression, substance, eating and borderline personality disorders: A systematic review. Clin Psychol Rev. 2017; 57:141-163. DOI: 10.1016/j.cpr.2017.09.002. View

12.

Williams Z, Schaaf R, Ausderau K, Baranek G, Barrett D, Cascio C . Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium. Mol Autism. 2023; 14(1):31. PMC: 10464466. DOI: 10.1186/s13229-023-00563-4. View

13.

Schoen S, Miller L, Sullivan J . Measurement in Sensory Modulation: the Sensory Processing Scale Assessment. Am J Occup Ther. 2014; 68(5):522-30. PMC: 4153553. DOI: 10.5014/ajot.2014.012377. View

14.

Kern J, Trivedi M, Garver C, Grannemann B, Andrews A, Savla J . The pattern of sensory processing abnormalities in autism. Autism. 2006; 10(5):480-94. DOI: 10.1177/1362361306066564. View

15.

Lazerwitz M, Rowe M, Trimarchi K, Garcia R, Chu R, Steele M . Brief Report: Characterization of Sensory Over-Responsivity in a Broad Neurodevelopmental Concern Cohort Using the Sensory Processing Three Dimensions (SP3D) Assessment. J Autism Dev Disord. 2022; 54(8):3185-3192. PMC: 9524317. DOI: 10.1007/s10803-022-05747-0. View

16.

Brandes-Aitken A, Anguera J, Rolle C, Desai S, Demopoulos C, Skinner S . Characterizing cognitive and visuomotor control in children with sensory processing dysfunction and autism spectrum disorders. Neuropsychology. 2018; 32(2):148-160. DOI: 10.1037/neu0000404. View

17.

Brown N, Dunn W . Relationship between context and sensory processing in children with autism. Am J Occup Ther. 2010; 64(3):474-83. DOI: 10.5014/ajot.2010.09077. View

18.

Miller L, Nielsen D, Schoen S . Attention deficit hyperactivity disorder and sensory modulation disorder: a comparison of behavior and physiology. Res Dev Disabil. 2012; 33(3):804-18. DOI: 10.1016/j.ridd.2011.12.005. View

19.

Demopoulos C, Brandes-Aitken A, Desai S, Hill S, Antovich A, Harris J . Shared and Divergent Auditory and Tactile Processing in Children with Autism and Children with Sensory Processing Dysfunction Relative to Typically Developing Peers. J Int Neuropsychol Soc. 2015; 21(6):444-54. DOI: 10.1017/S1355617715000387. View

20.

Baez A, Dajani D, Voorhies W, Parlade M, Alessandri M, Britton J . Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function. J Autism Dev Disord. 2019; 50(3):707-718. DOI: 10.1007/s10803-019-04290-9. View