Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species
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Abstract
Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein-expressing host. Those results indicated some CWD prions could acquire enhanced zoonotic properties following adaptation in an intermediate species.
References
1.
Padilla D, Beringue V, Espinosa J, Andreoletti O, Jaumain E, Reine F
. Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice. PLoS Pathog. 2011; 7(3):e1001319.
PMC: 3060172.
DOI: 10.1371/journal.ppat.1001319.
View
2.
Deslys J, Marce D, Dormont D
. Similar genetic susceptibility in iatrogenic and sporadic Creutzfeldt-Jakob disease. J Gen Virol. 1994; 75 ( Pt 1):23-7.
DOI: 10.1099/0022-1317-75-1-23.
View
3.
Hill A, Joiner S, Wadsworth J, Sidle K, Bell J, Budka H
. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain. 2003; 126(Pt 6):1333-46.
DOI: 10.1093/brain/awg125.
View
4.
Nonno R, Di Bari M, Pirisinu L, DAgostino C, Vanni I, Chiappini B
. Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America. Proc Natl Acad Sci U S A. 2020; 117(49):31417-31426.
PMC: 7733848.
DOI: 10.1073/pnas.2013237117.
View
5.
Torres J, Espinosa J, Aguilar-Calvo P, Herva M, Relano-Gines A, Villa-Diaz A
. Elements modulating the prion species barrier and its passage consequences. PLoS One. 2014; 9(3):e89722.
PMC: 3946430.
DOI: 10.1371/journal.pone.0089722.
View