Extract As a Source of Antimicrobial Compounds: A Circular Bioeconomy Approach

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2024 Nov 26

PMID 39590791

Authors

Roberta Barletta

Alfonso Trezza

Michela Geminiani

Luisa Frusciante

Tommaso Olmastroni

Filomena Sannio

Jean-Denis Docquier

Annalisa Santucci

Affiliations

Soon will be listed here.

Abstract

The circular bioeconomy is currently a promising model for repurposing natural sources; these sources include plants due to their abundance of bioactive compounds. This study evaluated the antimicrobial properties of a extract. is an invasive macroalga from the Orbetello Lagoon (Tuscany, Italy), which grows in nutrient-rich environments and has been forming extended mats since 2005. The biomass is mechanically harvested and treated as waste, consuming considerable manpower and financial resources. As a potential way to increase the value of such waste, this study found that extract (CLE) is a source of antimicrobial compounds. The phytochemical characterization of the extract revealed the predominant presence of palmitic acid, a fatty acid with known antimicrobial activity. Based on such findings, four bacterial species of high clinical relevance (, , , and ) were tested, revealing a notable antibacterial activity of the extract on (MIC, 32 μg/mL). Computational analyses identified a potential molecular target for palmitic acid, offering molecular insights on the interaction. This study presents a comprehensive in vitro and in silico approach for drug and target discovery studies by repurposing as a source of antimicrobial bioactive compounds.

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