Mesenchymal Stem Cells: Guardians of Women's Health

Overview

Journal Regen Ther

Date 2024 Nov 25

PMID 39582803

Authors

Guanwen Gao

Li Li

Changling Li

Degao Liu

Yunfei Wang

Changzhong Li

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) have attracted more and more attention because of their multidirectional differentiation potential, immune regulatory abilities and self-renewal capacity. In recent years, their use has become prominent in the domains of regenerative medicine and tissue engineering. MSCs have shown promise in therapeutic studies for a variety of diseases and have become a new source of innovative solutions for the treatment of some obstetric and gynecological diseases. This review systematically presents the latest research on the use of MSCs in the treatment of obstetrics- and gynecology-related diseases. Specifically, this review encompasses the latest findings related to the role of MSCs in premature ovarian failure, polycystic ovary syndrome, ovarian cancer, fallopian tube-related diseases, uterine adhesions, endometriosis, cesarean scar defects, postmenopausal osteoporosis, and pelvic floor dysfunction. The shortcomings and challenges of the future use of MSCs in disease treatment are also discussed, with the intent to motivate improvements in MSC applications in clinical therapy. It is believed that with further research, MSCs will play a more important role in the treatment of obstetrics- and gynecology-related diseases.

References

Li J, Yu Q, Huang H, Deng W, Cao X, Adu-Frimpong M . Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure. Stem Cell Res Ther. 2018; 9(1):81. PMC: 5883538. DOI: 10.1186/s13287-018-0819-z. View

Tsuji S, Mukai T, Tsuchiya H, Iwatani C, Nakamura A, Nagamura-Inoue T . Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis. Reprod Med Biol. 2023; 22(1):e12540. PMC: 10491929. DOI: 10.1002/rmb2.12540. View

May K, Becker C . Endometriosis and angiogenesis. Minerva Ginecol. 2008; 60(3):245-54. View

Davoodi Asl F, Sahraei S, Kalhor N, Fazaeli H, Sheykhhasan M, Soleimani Moud S . Promising effects of exosomes from menstrual blood-derived mesenchymal stem cells on endometriosis. Reprod Biol. 2023; 23(3):100788. DOI: 10.1016/j.repbio.2023.100788. View

Xu B, Cao Y, Zheng Z, Galan E, Hu Z, Ge J . Injectable Mesenchymal Stem Cell-Laden Matrigel Microspheres for Endometrium Repair and Regeneration. Adv Biol (Weinh). 2021; 5(8):e2000202. DOI: 10.1002/adbi.202000202. View

Sipahi S, Sasaki K, Miller C . The minimally invasive approach to the symptomatic isthmocele - what does the literature say? A step-by-step primer on laparoscopic isthmocele - excision and repair. Curr Opin Obstet Gynecol. 2017; 29(4):257-265. DOI: 10.1097/GCO.0000000000000380. View

Lu C, Chen Y, Ke C, Liu R . Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis. Int J Mol Sci. 2021; 22(23). PMC: 8657894. DOI: 10.3390/ijms222312750. View

Harrell C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V . Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells. 2019; 8(12). PMC: 6952783. DOI: 10.3390/cells8121605. View

Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, Oudit G . Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax. 2012; 68(5):475-84. DOI: 10.1136/thoraxjnl-2012-202323. View

10.

Mills G, Badeghiesh A, Suarthana E, Baghlaf H, Dahan M . Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies. Hum Reprod. 2020; 35(7):1666-1674. DOI: 10.1093/humrep/deaa099. View

11.

Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B . ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5):926-37. DOI: 10.1093/humrep/dew027. View

12.

Maiborodin I, Yakimova N, Matveyeva V, Pekarev O, Maiborodina E, Pekareva E . Angiogenesis in rat uterine cicatrix after injection of autologous bone marrow mesenchymal stem cells. Bull Exp Biol Med. 2012; 150(6):756-61. DOI: 10.1007/s10517-011-1242-y. View

13.

Shekari S, Stankovic S, Gardner E, Hawkes G, Kentistou K, Beaumont R . Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med. 2023; 29(7):1692-1699. DOI: 10.1038/s41591-023-02405-5. View

14.

Agic A, Xu H, Finas D, Banz C, Diedrich K, Hornung D . Is endometriosis associated with systemic subclinical inflammation?. Gynecol Obstet Invest. 2006; 62(3):139-47. DOI: 10.1159/000093121. View

15.

Qiu L, Wang J, Chen M, Chen F, Tu W . Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis. Int J Mol Med. 2020; 46(2):609-620. PMC: 7307828. DOI: 10.3892/ijmm.2020.4634. View

16.

Chu Y, Zhu C, Wang Q, Liu M, Wan W, Zhou J . Adipose-derived mesenchymal stem cells induced PAX8 promotes ovarian cancer cell growth by stabilizing TAZ protein. J Cell Mol Med. 2021; 25(9):4434-4443. PMC: 8093979. DOI: 10.1111/jcmm.16511. View

17.

Kiernan J, Hu S, Grynpas M, Davies J, Stanford W . Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age-Related Osteoporosis. Stem Cells Transl Med. 2016; 5(5):683-93. PMC: 4835247. DOI: 10.5966/sctm.2015-0231. View

18.

Cosgrove C, Salani R . Ovarian effects of radiation and cytotoxic chemotherapy damage. Best Pract Res Clin Obstet Gynaecol. 2018; 55:37-48. DOI: 10.1016/j.bpobgyn.2018.07.008. View

19.

Liu H, Zhang X, Zhang M, Zhang S, Li J, Zhang Y . Mesenchymal Stem Cell Derived Exosomes Repair Uterine Injury by Targeting Transforming Growth Factor-β Signaling. ACS Nano. 2024; 18(4):3509-3519. DOI: 10.1021/acsnano.3c10884. View

20.

Janssen K, Lin D, Hanzlicek B, Deng K, Balog B, van der Vaart C . Multiple doses of stem cells maintain urethral function in a model of neuromuscular injury resulting in stress urinary incontinence. Am J Physiol Renal Physiol. 2019; 317(4):F1047-F1057. PMC: 6880197. DOI: 10.1152/ajprenal.00173.2019. View