Soft Tissue Sarcomas at the Single-cell and Spatial Resolution: New Markers and Targets

Overview

Journal Cancer Gene Ther

Specialties Genetics
Oncology
Pharmacology

Date 2024 Nov 24

PMID 39582085

Authors

Maxim E Menyailo

Elena E Kopantseva

Anna A Khozyainova

Anastasia A Korobeynikova

Evgeny V Denisov

Affiliations

Soon will be listed here.

Abstract

Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in connective tissues embryologically derived from the mesenchyme. Due to their rarity, crucial information about their biology is still lacking. In recent years, single-cell and spatial analyses have opened up new horizons in oncology, leading to the possibility of characterizing the internal architecture of the tumor at the single-cell and spatial levels. This review summarizes the first results acquired through these revolutionary methods for different types of STS. We discuss tumor cell populations and their evolution, interactions between tumor cells and the microenvironment, new prognostic markers, and clinically important targets. Finally, we examine the challenges presented by the single-cell and spatial omics of STS and the future perspectives in this field.

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