The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2024 Nov 22

PMID 39576473

Authors

S N Koryakin

M V Troshina

E V Koryakina

V I Potetnya

A A Pichkunova

V O Saburov

E I Kazakov

A A Lychagin

S A Ivanov

A D Kaprin

V I Zverev

A Yu Presnyakov

Affiliations

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Abstract

Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton-neutron exposure.

References

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