Cerebrospinal Fluid Lymphocyte Subpopulations in Multiple Sclerosis

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 1986 Feb 1

PMID 3957623

Citations 1

Authors

M G Marrosu

C Cianchetti

M G Ennas

Affiliations

Soon will be listed here.

Abstract

T3+ (all-T) and T8+ (suppressor/cytotoxic) cells were studied in cerebrospinal fluid (CSF) from 24 patients with multiple sclerosis (MS) and from 24 subjects with various "non-immunological" disease (NID). MS patients were classed as (a) during the acute phase of the 1st episode of the disease, (b) in acute relapse, (c) with chronic progressive disease, (d) with increased or (e) normal CSF IgG content or (f) with neurological impairment (Kurtzke scale) less than or equal to 3 or (g) greater than 3. In MS cases considered as a whole a significant decrease in CSF T3+ cells was found compared to NID patients. When single groups were considered, T3+ cells decrease was significant in classes (b), (d) and (f). Significantly lower percentages of T8+ cells, compared to NID, were found in MS classes (a), (d) and (f).

Citing Articles

Cerebrospinal fluid and peripheral blood T-lymphocyte subsets in multiple sclerosis: monoclonal antibody analysis and correlations with clinical activity.

Salmaggi A, Bianchi G, Cerrato D, Lazzaroni M, MALESANI L, Nespolo A Ital J Neurol Sci. 1987; 8(4):327-30.

PMID: 2960634 DOI: 10.1007/BF02335734.

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