Influencing Factors and Preventive Measures of Infectious Complications After Intestinal Resection for Crohn's Disease

Overview

Journal World J Gastrointest Surg

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2024 Nov 22

PMID 39575275

Authors

Shi-Rong Lv

Xiao Huang

Li-Yun Zhou

Jie Shi

Chu-Chu Gong

Ming-Ke Wang

Ji-Shun Yang

Affiliations

Soon will be listed here.

Abstract

The incidence of Crohn's disease (CD) has increased in recent years, with most patients requiring intestinal resection. Complications after intestinal resection for CD can lead to poor prognosis and recurrence, among which infectious complications are the most common. This study aimed to investigate the common risk factors, including medications, preoperative nutritional status, surgery-related factors, microorganisms, lesion location and type, and so forth, causing infectious complications after intestinal resection for CD, and to propose corresponding preventive measures. The findings provided guidance for identifying susceptibility factors and the early intervention and prevention of infectious complications after intestinal resection for CD in clinical practice.

References

Julien C, Anakok E, Treton X, Nachury M, Nancey S, Buisson A . Impact of the Ileal Microbiota on Surgical Site Infections in Crohn's Disease: A Nationwide Prospective Cohort. J Crohns Colitis. 2022; 16(8):1211-1221. DOI: 10.1093/ecco-jcc/jjac026. View

Seminerio J, Koutroubakis I, Ramos-Rivers C, Hashash J, Dudekula A, Regueiro M . Impact of Obesity on the Management and Clinical Course of Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015; 21(12):2857-63. DOI: 10.1097/MIB.0000000000000560. View

Kanazawa A, Yamana T, Okamoto K, Sahara R . Risk factors for postoperative intra-abdominal septic complications after bowel resection in patients with Crohn's disease. Dis Colon Rectum. 2012; 55(9):957-62. DOI: 10.1097/DCR.0b013e3182617716. View

Cima R, Bergquist J, Hanson K, Thiels C, Habermann E . Outcomes are Local: Patient, Disease, and Procedure-Specific Risk Factors for Colorectal Surgical Site Infections from a Single Institution. J Gastrointest Surg. 2017; 21(7):1142-1152. DOI: 10.1007/s11605-017-3430-1. View

Hellmann J, Andersen H, Fei L, Linn A, Bezold R, Lake K . Microbial Shifts and Shorter Time to Bowel Resection Surgery Associated with C. difficile in Pediatric Crohn's Disease. Inflamm Bowel Dis. 2019; 26(8):1212-1221. PMC: 7365806. DOI: 10.1093/ibd/izz263. View

Zhu Y, Zhou W, Qi W, Liu W, Chen M, Zhu H . Body mass index is a practical preoperative nutritional index for postoperative infectious complications after intestinal resection in patients with Crohn's disease. Medicine (Baltimore). 2017; 96(23):e7113. PMC: 5466238. DOI: 10.1097/MD.0000000000007113. View

Ghoneima A, Flashman K, Dawe V, Baldwin E, Celentano V . High risk of septic complications following surgery for Crohn's disease in patients with preoperative anaemia, hypoalbuminemia and high CRP. Int J Colorectal Dis. 2019; 34(12):2185-2188. DOI: 10.1007/s00384-019-03427-7. View

Xie T, Zhao C, Ding C, Zhang L, Cheng M, Chun C . Postoperative Interleukin-6 Predicts Intra-abdominal Septic Complications at an Early Stage After Elective Intestinal Operation for Crohn's Disease Patients. Inflamm Bowel Dis. 2018; 24(9):1992-2000. DOI: 10.1093/ibd/izy090. View

Meima-van Praag E, Buskens C, Hompes R, Bemelman W . Surgical management of Crohn's disease: a state of the art review. Int J Colorectal Dis. 2021; 36(6):1133-1145. PMC: 8119249. DOI: 10.1007/s00384-021-03857-2. View

10.

Yu X, Zhou L, Huang X, Li X, Pan Q, Wang M . Urgent call for attention to diabetes-associated hospital infections. World J Diabetes. 2024; 15(8):1683-1691. PMC: 11346093. DOI: 10.4239/wjd.v15.i8.1683. View

11.

Ikeshima R, Mizushima T, Takahashi H, Haraguchi N, Nishimura J, Hata T . The efficacy of active drainage for preventing postoperative organ/space surgical site infections in patients with Crohn's disease. Surg Today. 2017; 48(1):25-32. DOI: 10.1007/s00595-017-1549-z. View

12.

Trifan A, Stanciu C, Stoica O, Girleanu I, Cojocariu C . Impact of Clostridium difficile infection on inflammatory bowel disease outcome: a review. World J Gastroenterol. 2014; 20(33):11736-42. PMC: 4155363. DOI: 10.3748/wjg.v20.i33.11736. View

13.

Cai X, Shen W, Guo Z, Li Y, Cao L, Gong J . Thickness of Subcutaneous Fat Is a Predictive Factor of Incisional Surgical Site Infection in Crohn's Disease Surgery: A Retrospective Study. Gastroenterol Res Pract. 2018; 2018:1546075. PMC: 6081597. DOI: 10.1155/2018/1546075. View

14.

Shah R, Bachour S, Jia X, Holubar S, Hull T, Achkar J . Hypoalbuminaemia, Not Biologic Exposure, Is Associated with Postoperative Complications in Crohn's Disease Patients Undergoing Ileocolic Resection. J Crohns Colitis. 2021; 15(7):1142-1151. PMC: 8427722. DOI: 10.1093/ecco-jcc/jjaa268. View

15.

Lichtenstein G, Feagan B, Cohen R, Salzberg B, Diamond R, Chen D . Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol. 2006; 4(5):621-30. DOI: 10.1016/j.cgh.2006.03.002. View

16.

Jenks P, Laurent M, McQuarry S, Watkins R . Clinical and economic burden of surgical site infection (SSI) and predicted financial consequences of elimination of SSI from an English hospital. J Hosp Infect. 2013; 86(1):24-33. DOI: 10.1016/j.jhin.2013.09.012. View

17.

Canedo J, Lee S, Pinto R, Murad-Regadas S, Rosen L, Wexner S . Surgical resection in Crohn's disease: is immunosuppressive medication associated with higher postoperative infection rates?. Colorectal Dis. 2010; 13(11):1294-8. DOI: 10.1111/j.1463-1318.2010.02469.x. View

18.

Han Y, Kim J, Koh S, Kim B, Lee K, Im J . Patients with perianal Crohn's disease have poor disease outcomes after primary bowel resection. J Gastroenterol Hepatol. 2016; 31(8):1436-42. DOI: 10.1111/jgh.13310. View

19.

Wang F, Lin Y, Yuan X, Gao R, Wu X, Xu W . Predicting short-term major postoperative complications in intestinal resection for Crohn's disease: A machine learning-based study. World J Gastrointest Surg. 2024; 16(3):717-730. PMC: 10989335. DOI: 10.4240/wjgs.v16.i3.717. View

20.

Li Y, Stocchi L, Rui Y, Liu G, Gorgun E, Remzi F . Perioperative Blood Transfusion and Postoperative Outcome in Patients with Crohn's Disease Undergoing Primary Ileocolonic Resection in the "Biological Era". J Gastrointest Surg. 2015; 19(10):1842-51. DOI: 10.1007/s11605-015-2893-1. View