Anterior Pituitary Hormones Are Important in Growth, but Does Their Deficiency Cause Skeletal Deformity? A Case Report

Overview

Journal Curr Health Sci J

Specialty General Medicine

Date 2024 Nov 22

PMID 39574815

Authors

Yasemin Yumusakhuylu

Afitap Icagasioglu

Ayla Guven

Affiliations

Soon will be listed here.

Abstract

Hypopituitarism is a clinical syndrome that occurs when the anterior pituitary gland fails to secrete one or more hormones. Developmental delay is frequently seen in these patients. However, skeletal deformities and postural instability are unexceptional. We present a 17-year-old male patient with panhypopituitarism (PHP) with back and leg pain, postural malalignment, and skeletal deformities referred by the pediatric endocrinology clinic. According to the physical examination, laboratory tests, and radiographic assessments, the patient was considered as sequela spondyloarthropathy (SpA). Autoimmune and rheumatic diseases are frequently encountered in patients with hypogonadism. However, the association of PHP and ankylosing spondylitis (AS) has not yet been demonstrated. This case was presented to draw attention to the alignment of PHP and SpA and also to emphasize that skeletal deformities were not encountered in the absence of anterior hypophysis hormones.

References

Sawacha Z, Carraro E, Del Din S, Guiotto A, Bonaldo L, Punzi L . Biomechanical assessment of balance and posture in subjects with ankylosing spondylitis. J Neuroeng Rehabil. 2012; 9:63. PMC: 3517897. DOI: 10.1186/1743-0003-9-63. View

Perez-Garcia L, Te Winkel B, Carrizales J, Bramer W, Vorstenbosch S, van Puijenbroek E . Sexual function and reproduction can be impaired in men with rheumatic diseases: A systematic review. Semin Arthritis Rheum. 2020; 50(3):557-573. DOI: 10.1016/j.semarthrit.2020.02.002. View

Diack N, Ndiaye N, Mbaye A, Kane B, Leye A . Hypogonadotropic Hypogonadism and Juvenile Idiopathic Arthritis in an African Boy: What is the Pathophysiological Link?. Cureus. 2020; 12(11):e11337. PMC: 7719468. DOI: 10.7759/cureus.11337. View

Barut K, Adrovic A, Sahin S, Kasapcopur O . Juvenile Idiopathic Arthritis. Balkan Med J. 2017; 34(2):90-101. PMC: 5394305. DOI: 10.4274/balkanmedj.2017.0111. View

Kalyani R, Gavini S, Dobs A . Male hypogonadism in systemic disease. Endocrinol Metab Clin North Am. 2007; 36(2):333-48. DOI: 10.1016/j.ecl.2007.03.014. View

Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X . ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann Rheum Dis. 2022; 82(1):19-34. DOI: 10.1136/ard-2022-223296. View

Hong H, Pan X, Song J, Fang N, Yang R, Xiang L . Idiopathic short stature and scoliosis in children treated with growth hormone. Bone Joint J. 2023; 105-B(4):439-448. DOI: 10.1302/0301-620X.105B4.BJJ-2022-0898.R1. View

Olivieri I, van Tubergen A, Salvarani C, van der Linden S . Seronegative spondyloarthritides. Best Pract Res Clin Rheumatol. 2002; 16(5):723-39. DOI: 10.1053/berh.2002.0263. View

Lindsey R, Mohan S . Skeletal effects of growth hormone and insulin-like growth factor-I therapy. Mol Cell Endocrinol. 2015; 432:44-55. PMC: 4808510. DOI: 10.1016/j.mce.2015.09.017. View

10.

Jimenez-Balderas F, Fonseca M, Arellano J, Beltran A, Yanez P, Camargo-Coronel A . High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction. Arthritis Res. 2001; 3(6):362-7. PMC: 64847. DOI: 10.1186/ar328. View

11.

Niwczyk O, Grymowicz M, Szczesnowicz A, Hajbos M, Kostrzak A, Budzik M . Bones and Hormones: Interaction between Hormones of the Hypothalamus, Pituitary, Adipose Tissue and Bone. Int J Mol Sci. 2023; 24(7). PMC: 10094866. DOI: 10.3390/ijms24076840. View

12.

Baillargeon J, Al Snih S, Raji M, Urban R, Sharma G, Sheffield-Moore M . Hypogonadism and the risk of rheumatic autoimmune disease. Clin Rheumatol. 2016; 35(12):2983-2987. PMC: 5544431. DOI: 10.1007/s10067-016-3330-x. View

13.

Braun J, Sieper J . Ankylosing spondylitis. Lancet. 2007; 369(9570):1379-1390. DOI: 10.1016/S0140-6736(07)60635-7. View

14.

De Nunzio A, Iervolino S, Zincarelli C, Di Gioia L, Rengo G, Multari V . Ankylosing spondylitis and posture control: the role of visual input. Biomed Res Int. 2015; 2015:948674. PMC: 4363712. DOI: 10.1155/2015/948674. View

15.

Wiese J, El Ghezewi A, Mohamed M, Joshi T, Frandah W . A Rare Case of Severe Jaundice in a Panhypopituitarism Patient. J Med Cases. 2023; 14(6):204-207. PMC: 10332867. DOI: 10.14740/jmc4102. View

16.

Muthu S, Chellamuthu G, Gopalswamy T, Kandasamy V . Surgical strategies in management of ankylosed bilateral hips and knees in crouched posture. BMJ Case Rep. 2020; 13(10). PMC: 7604799. DOI: 10.1136/bcr-2020-236043. View

17.

Baraliakos X, Braun J . Hip involvement in ankylosing spondylitis: what is the verdict?. Rheumatology (Oxford). 2009; 49(1):3-4. DOI: 10.1093/rheumatology/kep298. View