A Comprehensive Review of Naringenin, a Promising Phytochemical with Therapeutic Potential

Overview

Journal J Microbiol Biotechnol

Specialties Biotechnology
Microbiology

Date 2024 Nov 21

PMID 39572023

Authors

Jun Hong Shin

Seung Ho Shin

Affiliations

Soon will be listed here.

Abstract

Disorders, including cancer, metabolic disorders, and neurodegenerative diseases, can threaten human health; therefore, disease prevention is essential. Naringenin, a phytochemical with low toxicity, has been used in various disease prevention studies. This study aimed to comprehensively review the effects of naringenin on human health. First, we introduced the general characteristics of naringenin and its pharmacokinetic features when absorbed in the body. Next, we summarized the inhibitory effects of naringenin on colorectal, gastric, lung, breast, ovarian, cervical, prostate, bladder, liver, pancreatic, and skin cancers in preclinical studies. Lastly, we investigated the inhibitory effects of naringenin on metabolic disorders, including diabetes, obesity, hyperlipidemia, hypertension, cardiac toxicity, hypertrophy, steatosis, liver disease, and arteriosclerosis, as well as on neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, naringenin may serve as a significant natural compound that benefits human health.

References

Patra S, Pradhan B, Nayak R, Behera C, Das S, Patra S . Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action. Phytomedicine. 2021; 90:153554. DOI: 10.1016/j.phymed.2021.153554. View

Mutlur Krishnamoorthy R, Venkatraman A . Polyphenols activate energy sensing network in insulin resistant models. Chem Biol Interact. 2017; 275:95-107. DOI: 10.1016/j.cbi.2017.07.016. View

Rakhra V, Galappaththy S, Bulchandani S, Cabandugama P . Obesity and the Western Diet: How We Got Here. Mo Med. 2020; 117(6):536-538. PMC: 7721435. View

Oyagbemi A, Omobowale T, Adejumobi O, Owolabi A, Ogunpolu B, Falayi O . Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway. Eur J Pharmacol. 2020; 880:173142. DOI: 10.1016/j.ejphar.2020.173142. View

Qin L, Jin L, Lu L, Lu X, Zhang C, Zhang F . Naringenin reduces lung metastasis in a breast cancer resection model. Protein Cell. 2011; 2(6):507-16. PMC: 4875175. DOI: 10.1007/s13238-011-1056-8. View

Wang R, Wang J, Dong T, Shen J, Gao X, Zhou J . Naringenin has a chemoprotective effect in MDA-MB-231 breast cancer cells via inhibition of caspase-3 and -9 activities. Oncol Lett. 2019; 17(1):1217-1222. PMC: 6312985. DOI: 10.3892/ol.2018.9704. View

Peng H, Cheng F, Huang Y, Chen C, Tsai T . Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998; 714(2):369-74. DOI: 10.1016/s0378-4347(98)00204-7. View

Reith W . [Neurodegenerative diseases]. Radiologe. 2018; 58(3):241-258. DOI: 10.1007/s00117-018-0363-y. View

Simola N, Morelli M, Carta A . The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res. 2007; 11(3-4):151-67. DOI: 10.1007/BF03033565. View

10.

Jin C, Park C, Hwang H, Kim G, Choi B, Kim W . Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells. Mol Nutr Food Res. 2010; 55(2):300-9. DOI: 10.1002/mnfr.201000024. View

11.

Harmon A, Patel Y . Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferation. Breast Cancer Res Treat. 2004; 85(2):103-10. DOI: 10.1023/B:BREA.0000025397.56192.e2. View

12.

von dem Knesebeck O, Ludecke D, Luck-Sikorski C, Kim T . Public beliefs about causes of obesity in the USA and in Germany. Int J Public Health. 2019; 64(8):1139-1146. DOI: 10.1007/s00038-019-01295-0. View

13.

Chen T, Wu H, He Y, Pan W, Yan Z, Liao Y . Simultaneously Quantitative Analysis of Naringin and Its Major Human Gut Microbial Metabolites Naringenin and 3-(4'-Hydroxyphenyl) Propanoic Acid via Stable Isotope Deuterium-Labeling Coupled with RRLC-MS/MS Method. Molecules. 2019; 24(23). PMC: 6930535. DOI: 10.3390/molecules24234287. View

14.

Guarente L . Sirtuins as potential targets for metabolic syndrome. Nature. 2006; 444(7121):868-74. DOI: 10.1038/nature05486. View

15.

Lim W, Park S, Bazer F, Song G . Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways. J Cell Biochem. 2016; 118(5):1118-1131. DOI: 10.1002/jcb.25729. View

16.

Yen H, Liu C, Yeh C . Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015; 235:1-9. DOI: 10.1016/j.cbi.2015.04.003. View

17.

Zella M, Metzdorf J, Ostendorf F, Maass F, Muhlack S, Gold R . Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease. Cells. 2019; 8(2). PMC: 6406239. DOI: 10.3390/cells8020105. View

18.

Lin S, Hou Y, Tsai S, Wang M, Chao P . Tissue distribution of naringenin conjugated metabolites following repeated dosing of naringin to rats. Biomedicine (Taipei). 2014; 4:16. PMC: 4265019. DOI: 10.7603/s40681-014-0016-z. View

19.

Carey R, Muntner P, Bosworth H, Whelton P . Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018; 72(11):1278-1293. PMC: 6481176. DOI: 10.1016/j.jacc.2018.07.008. View

20.

Kannappan S, Anuradha C . Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome. Eur J Nutr. 2009; 49(2):101-9. DOI: 10.1007/s00394-009-0054-6. View