» Articles » PMID: 39565521

A Method for Detecting Depression in Adolescence Based on an Affective Brain-Computer Interface and Resting-State Electroencephalogram Signals

Overview
Journal Neurosci Bull
Specialty Neurology
Date 2024 Nov 20
PMID 39565521
Authors
Affiliations
Soon will be listed here.
Abstract

Depression is increasingly prevalent among adolescents and can profoundly impact their lives. However, the early detection of depression is often hindered by the time-consuming diagnostic process and the absence of objective biomarkers. In this study, we propose a novel approach for depression detection based on an affective brain-computer interface (aBCI) and the resting-state electroencephalogram (EEG). By fusing EEG features associated with both emotional and resting states, our method captures comprehensive depression-related information. The final depression detection model, derived through decision fusion with multiple independent models, further enhances detection efficacy. Our experiments involved 40 adolescents with depression and 40 matched controls. The proposed model achieved an accuracy of 86.54% on cross-validation and 88.20% on the independent test set, demonstrating the efficiency of multimodal fusion. In addition, further analysis revealed distinct brain activity patterns between the two groups across different modalities. These findings hold promise for new directions in depression detection and intervention.

References
1.
Malhi G, Mann J . Depression. Lancet. 2018; 392(10161):2299-2312. DOI: 10.1016/S0140-6736(18)31948-2. View

2.
Horowitz M, Zunszain P . Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin. Ann N Y Acad Sci. 2015; 1351:68-79. DOI: 10.1111/nyas.12781. View

3.
Hosokawa T, Momose T, Kasai K . Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 33(2):243-50. DOI: 10.1016/j.pnpbp.2008.11.014. View

4.
Haapakoski R, Mathieu J, Ebmeier K, Alenius H, Kivimaki M . Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun. 2015; 49:206-15. PMC: 4566946. DOI: 10.1016/j.bbi.2015.06.001. View

5.
Saeb S, Lonini L, Jayaraman A, Mohr D, Kording K . The need to approximate the use-case in clinical machine learning. Gigascience. 2017; 6(5):1-9. PMC: 5441397. DOI: 10.1093/gigascience/gix019. View