Neddylation of Protein, a New Strategy of Protein Post-translational Modification for Targeted Treatment of Central Nervous System Diseases

Overview

Journal Front Neurosci

Date 2024 Nov 20

PMID 39564524

Authors

Qian Wu

Ziang Geng

Jun Lu

Shisong Wang

Zhongxue Yu

Siqi Wang

Xiaolin Ren

Shu Guan

Tiancong Liu

Chen Zhu

Affiliations

Soon will be listed here.

Abstract

Neddylation, a type of protein post-translational modification that links the ubiquitin-like protein NEDD8 to substrate proteins, can be involved in various significant cellular processes and generate multiple biological effects. Currently, the best-characterized substrates of neddylation are the Cullin protein family, which is the core subunit of the Cullin-RING E3 ubiquitin ligase complex and controls many important biological processes by promoting ubiquitination and subsequent degradation of various key regulatory proteins. The normal or abnormal process of protein neddylation in the central nervous system can lead to a series of occurrences of normal functions and the development of diseases, providing an attractive, reasonable, and effective targeted therapeutic strategy. Therefore, this study reviews the phenomenon of neddylation in the central nervous system and summarizes the corresponding substrates. Finally, we provide a detailed description of neddylation involved in CNS diseases and treatment methods that may be used to regulate neddylation for the treatment of related diseases.

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