Adult-onset Pancreatic Neuroblastoma: A Case Report with a Literature Review

Overview

Journal Radiol Case Rep

Publisher Elsevier

Specialty Radiology

Date 2024 Nov 19

PMID 39559503

Authors

Noufel Alshadood

Ali Naser Aldarawsha

Sajjad Ghanim Al-Badri

Mohamed Samy Elazab

Manar Mohammed Mahdi

Flayyih Hasan Yousif

Asdah Alawad

Nabeel Al-Fatlawi

Abbas Hamza Abbas

Alaa Saeed AbdAli

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is an aggressive malignancy commonly found in children, with adult patients being quite rare. Pancreatic neuroblastoma, even among adult cases, is especially rare. We present a case of a 26-year-old woman presented with mild abdominal pain and a palpable mass diagnosed as neuroblastoma affecting the pancreas. After initial diagnostic challenges, a biopsy confirmed the diagnosis of neuroblastoma. The patient thereafter underwent a course of neoadjuvant chemotherapy, followed by a complex surgical resection. This case highlights the importance of a comprehensive diagnostic approach, including repeated biopsies and the involvement of a multidisciplinary team in the management of rare presentations of adult neuroblastoma.

References

Carlsen N, Christensen I, Schroeder H, Bro P, Erichsen G, Jensen K . Prognostic factors in neuroblastomas treated in Denmark from 1943 to 1980. A statistical estimate of prognosis based on 253 cases. Cancer. 1986; 58(12):2726-35. DOI: 10.1002/1097-0142(19861215)58:12<2726::aid-cncr2820581229>3.0.co;2-m. View

Galgano S, Royal S . Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome. Radiol Case Rep. 2016; 11(1):36-40. PMC: 4769609. DOI: 10.1016/j.radcr.2015.09.003. View

Lopez R, Karakousis C, Rao U . Treatment of adult neuroblastoma. Cancer. 1980; 45(5):840-4. DOI: 10.1002/1097-0142(19800301)45:5<840::aid-cncr2820450503>3.0.co;2-z. View

Monclair T, Brodeur G, Ambros P, Brisse H, Cecchetto G, Holmes K . The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 2008; 27(2):298-303. PMC: 2650389. DOI: 10.1200/JCO.2008.16.6876. View

Kargl S, Frechinger B, Pumberger W . Perinatal neuroblastoma of the pancreas. Pediatr Surg Int. 2012; 28(12):1239-41. DOI: 10.1007/s00383-012-3179-2. View

Rosenbaum D, Abramson S, DeLappe E, Teruya-Feldstein J, La Quaglia M, Fox J . Pancreatic involvement in neuroblastoma with radiologic-pathologic correlation: a single-institution experience. AJR Am J Roentgenol. 2013; 201(1):W141-6. DOI: 10.2214/AJR.12.9618. View

FRANKS L, Bollen A, Seeger R, Stram D, Matthay K . Neuroblastoma in adults and adolescents: an indolent course with poor survival. Cancer. 1997; 79(10):2028-35. DOI: 10.1002/(sici)1097-0142(19970515)79:10<2028::aid-cncr26>3.0.co;2-v. View

Klingebiel T, Bader P, Bares R, Beck J, Hero B, Jurgens H . Treatment of neuroblastoma stage 4 with 131I-meta-iodo-benzylguanidine, high-dose chemotherapy and immunotherapy. A pilot study. Eur J Cancer. 1998; 34(9):1398-402. DOI: 10.1016/s0959-8049(98)00130-0. View

Suzuki M, Kushner B, Kramer K, Basu E, Roberts S, Hammond W . Treatment and outcome of adult-onset neuroblastoma. Int J Cancer. 2018; 143(5):1249-1258. PMC: 6103828. DOI: 10.1002/ijc.31399. View

10.

Hartmann O, Valteau-Couanet D, Vassal G, Lapierre V, Brugieres L, Delgado R . Prognostic factors in metastatic neuroblastoma in patients over 1 year of age treated with high-dose chemotherapy and stem cell transplantation: a multivariate analysis in 218 patients treated in a single institution. Bone Marrow Transplant. 1999; 23(8):789-95. DOI: 10.1038/sj.bmt.1701737. View

11.

Yanik G, Parisi M, Shulkin B, Naranjo A, Kreissman S, London W . Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children's oncology group. J Nucl Med. 2013; 54(4):541-8. PMC: 5503147. DOI: 10.2967/jnumed.112.112334. View

12.

Abdou A, Asaad N, Elkased A, Said H, Dawoud M . Adult pancreatic neuroblastoma, an unusual site and fatal outcome. Pathol Oncol Res. 2011; 18(2):239-43. DOI: 10.1007/s12253-011-9434-3. View

13.

Brisse H, McCarville M, Granata C, Krug K, Wootton-Gorges S, Kanegawa K . Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology. 2011; 261(1):243-57. DOI: 10.1148/radiol.11101352. View

14.

Cai J, Pan C, Tang Y, Chen J, Zhou M, Li B . Multivariate analysis of risk factors for patients with stage 4 neuroblastoma who were older than 18 months at diagnosis: a report from a single institute in Shanghai, China. J Cancer Res Clin Oncol. 2017; 143(7):1327-1335. DOI: 10.1007/s00432-017-2379-5. View

15.

El-Sayed M, Ali A, Sayed H, Zaky E . Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study. Int Arch Med. 2010; 3:37. PMC: 3018370. DOI: 10.1186/1755-7682-3-37. View