Synthesis of Pyrrole-fused Dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine Derivatives Via Isocyanide-based Multicomponent Reactions

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2024 Nov 19

PMID 39559445

Authors

Marzieh Norouzi

Mohammad Taghi Nazeri

Ahmad Shaabani

Behrouz Notash

Affiliations

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Abstract

An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives was developed through the isocyanide-based multicomponent reaction of isocyanides, -diactivated olefins, and cyclic imines such as dibenzoxazepine, dibenzothiazepine, and triazolobenzodiazepine under solvent- and catalyst-free conditions. Purposefully, this approach produced various bioactive scaffolds using environmentally friendly, mild, and simple conditions. Due to their bioactive moieties, these compounds with exclusive fluorescence properties may attract great attention in biomedical applications, clinical diagnostics, and conjugate materials.

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