Incidence, Epidemiology, Radiology, and Classification of Metastatic Spine Tumors: WFNS Spine Committee Recommendations

Overview

Journal Neurosurg Rev

Specialty Neurosurgery

Date 2024 Nov 16

PMID 39549161

Authors

Francesco Costa

Francesco Restelli

Niccolo Innocenti

Mehmet Zileli

Sandeep Vaishya

Corinna Zygourakis

Mirza Pojskic

Onur Yaman

Salman Sharif

Affiliations

Soon will be listed here.

Abstract

Spinal metastasis (SMs) are the most encountered tumors of the spine. Their occurrence is expected roughly around one to two years after primary tumor diagnosis. Since the advent of Magnetic Resonance Imaging (MRI), this technology has been considered the gold standard for SMs diagnosis and characterization due to its precise ability to comprehend the rate of soft tissue compression/invasion (dural sac/nervous tissue), which is one of the main drivers of management strategies. Computed Tomography (CT) remains unbeatable when a detailed bony anatomy and instability assessment is searched. Nuclear medicine technologies may have a role in diagnosis when standard MR or CT study findings are inconclusive or when the extent of the systemic metastatic disease is studied. The main objective of this study is to offer an update on the epidemiology and radiology of spinal metastasis (SMs), endorsed by the WFNS Spine Committee. A systematic review of the literature of the last ten years gave 1531 results with "spine/spinal metastatic tumors/metastasis AND radiology OR imaging OR classification" as search strings in all fields, of which 56 papers were fully analyzed. The results were discussed and voted on in two consensus meetings of the WFNS (World Federation of Neurosurgical Societies) Spine Committee, reaching a positive or negative consensus using the Delphi method. The committee stated nine recommendations on two main topics: (1) Incidence and epidemiology of SMs; (2) Radiology and classifications of SMs.

References

Van den Brande R, Cornips E, Peeters M, Ost P, Billiet C, Van de Kelft E . Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review. J Bone Oncol. 2022; 35:100446. PMC: 9289863. DOI: 10.1016/j.jbo.2022.100446. View

Rostami R, Safarpour D, Tavassoli F, Jabbari B . Intramedullary metastasis in breast cancer--a comprehensive literature review. J Neurol Sci. 2013; 332(1-2):16-20. DOI: 10.1016/j.jns.2013.05.032. View

Curtin M, Piggott R, Murphy E, Munigangaiah S, Baker J, McCabe J . Spinal Metastatic Disease: A Review of the Role of the Multidisciplinary Team. Orthop Surg. 2017; 9(2):145-151. PMC: 6584164. DOI: 10.1111/os.12334. View

Basdelioglu K . Features of Spinal Metastases: A Retrospective View. Int J Spine Surg. 2021; 15(1):119-129. PMC: 7931703. DOI: 10.14444/8016. View

Boaro A, Wells M, Chi J, Lu Y, Smith T, Groff M . A National Surgical Quality Improvement Program Analysis of Postoperative Major and Minor Complications in Patients with Spinal Metastatic Disease. World Neurosurg. 2020; 140:e203-e211. DOI: 10.1016/j.wneu.2020.04.225. View

Horn S, Dhillon E, Poorman G, Tishelman J, Segreto F, Bortz C . Epidemiology and national trends in prevalence and surgical management of metastatic spinal disease. J Clin Neurosci. 2018; 53:183-187. DOI: 10.1016/j.jocn.2018.04.022. View

Sohn S, Kim J, Chung C, Lee N, Park E, Chang U . A nationwide epidemiological study of newly diagnosed spine metastasis in the adult Korean population. Spine J. 2016; 16(8):937-45. DOI: 10.1016/j.spinee.2016.03.006. View

Amelot A, Balabaud L, Choi D, Fox Z, Crockard H, Albert T . Surgery for metastatic spine tumors in the elderly. Advanced age is not a contraindication to surgery!. Spine J. 2015; 17(6):759-767. DOI: 10.1016/j.spinee.2015.07.440. View

Choi S, Koo J, Choe D, Kang C . The Incidence and Management Trends of Metastatic Spinal Tumors in South Korea: A Nationwide Population-based Study. Spine (Phila Pa 1976). 2020; 45(14):E856-E863. DOI: 10.1097/BRS.0000000000003445. View

10.

Kelly M, Kshettry V, Rosenbaum B, Seicean A, Weil R . Effect of a randomized controlled trial on the surgical treatment of spinal metastasis, 2000 through 2010: a population-based cohort study. Cancer. 2013; 120(6):901-8. DOI: 10.1002/cncr.28497. View

11.

Onken J, Fekonja L, Wehowsky R, Hubertus V, Vajkoczy P . Metastatic dissemination patterns of different primary tumors to the spine and other bones. Clin Exp Metastasis. 2019; 36(6):493-498. DOI: 10.1007/s10585-019-09987-w. View

12.

Zhang H, Qiao R, Yang X, Hu Y . A multicenter, descriptive epidemiologic survey of the clinical features of spinal metastatic disease in China. Neurol Res. 2020; 42(9):749-759. DOI: 10.1080/01616412.2020.1773630. View

13.

Sailhan F, Prost S, Zairi F, Gille O, Pascal-Mousselard H, Bennis S . Retrospective multicenter study by the French Spine Society of surgical treatment for spinal metastasis in France. Orthop Traumatol Surg Res. 2018; 104(5):589-595. DOI: 10.1016/j.otsr.2018.06.006. View

14.

Gao Q, Yang D, Yuan Z, Guo Y . Prognostic factors and its predictive value in patients with metastatic spinal cancer. World J Clin Cases. 2021; 9(20):5470-5478. PMC: 8281408. DOI: 10.12998/wjcc.v9.i20.5470. View

15.

Gao X, Pan R, Chen M, Zhao J, Zhong W, Wang H . Leptomeningeal enhancement in magnetic resonance imaging predicts poor prognosis in lung adenocarcinoma patients with leptomeningeal metastasis. Thorac Cancer. 2022; 13(7):1059-1066. PMC: 8977178. DOI: 10.1111/1759-7714.14362. View

16.

Gu R, Liu J, Zhang Q, Liu G, Zhu Q . MRI diagnosis of intradural extramedullary tumors. J Cancer Res Ther. 2015; 10(4):927-31. DOI: 10.4103/0973-1482.137993. View

17.

Khan M, Garg R, Gui C, Lee Y, Sahgal A, Mossa-Basha M . Neuroimaging and Stereotactic Body Radiation Therapy (SBRT) for Spine Metastasis. Top Magn Reson Imaging. 2019; 28(2):85-96. DOI: 10.1097/RMR.0000000000000199. View

18.

Mauch J, Carr C, Cloft H, Diehn F . Review of the Imaging Features of Benign Osteoporotic and Malignant Vertebral Compression Fractures. AJNR Am J Neuroradiol. 2018; 39(9):1584-1592. PMC: 7655272. DOI: 10.3174/ajnr.A5528. View

19.

Isaac A, Dalili D, Dalili D, Weber M . State-of-the-art imaging for diagnosis of metastatic bone disease. Radiologe. 2020; 60(Suppl 1):1-16. PMC: 7686212. DOI: 10.1007/s00117-020-00666-6. View

20.

Husain Z, Sahgal A, Chang E, Jabehdar Maralani P, Kubicky C, Redmond K . Modern approaches to the management of metastatic epidural spinal cord compression. CNS Oncol. 2017; . PMC: 6009217. DOI: 10.2217/cns-2016-0044. View