Natural Compounds Modulate the Mechanism of Action of Tumour-associated Macrophages Against Colorectal Cancer: a Review

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2024 Nov 15

PMID 39546016

Authors

Weichen Yuan

Jiexiang Zhang

Haibin Chen

Yupei Zhuang

Hongli Zhou

Wenting Li

Wenli Qiu

Hongguang Zhou

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology and pathogenesis remain elusive. It holds significant importance within the tumour microenvironment (TME) and exerts a crucial regulatory influence on tumorigenesis, progression, and metastasis. TAMs possess the capability to foster CRC pathogenesis, proliferation, invasion, and metastasis, as well as angiogenesis, immune evasion, and tumour resistance. Furthermore, TAMs can mediate the prognosis of CRC. In this paper, we review the mechanisms by which natural compounds target TAMs to exert anti-CRC effects from the perspective of the promotional effects of TAMs on CRC, mainly regulating the polarization of TAMs, reducing the infiltration and recruitment of TAMs, enhancing the phagocytosis of macrophages, and regulating the signalling pathways and cytokines, and discuss the potential value and therapeutic strategies of natural compounds-targeting the TAMs pathway in CRC clinical treatment.

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