Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex

Overview

Journal Clin Cancer Res

Specialty Oncology

Date 2024 Nov 14

PMID 39540884

Authors

Kris Ann P Schultz

Suzanne P MacFarland

Melissa R Perrino

Sarah G Mitchell

Junne Kamihara

Alexander T Nelson

Paige H R Mallinger

Jack J Brzezinski

Kara N Maxwell

Emma R Woodward

Bailey Gallinger

Sun Young Kim

Mary-Louise C Greer

Kami Wolfe Schneider

Sarah R Scollon

Anirban Das

Jonathan D Wasserman

Charis Eng

David Malkin

William D Foulkes

Orli Michaeli

Andrew J Bauer

Douglas R Stewart

Affiliations

Soon will be listed here.

Abstract

Phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex are rare conditions, which each increases risk for distinct spectra of benign and malignant neoplasms throughout childhood and adulthood. Surveillance considerations for each of these conditions focus on patient and family education, early detection, and multidisciplinary care. In this article, we present updated surveillance recommendations and considerations for children and adolescents with phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex and provide suggestions for further research in each of these conditions.

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