Older Adults with Ph Negative Acute Lymphoblastic Leukemia: A Monocentric Experience on 57 Patients Focusing on Treatment Intensity and Age-Related Prognosis

Overview

Journal Mediterr J Hematol Infect Dis

Specialty Infectious Diseases

Date 2024 Nov 13

PMID 39534710

Authors

Erika Borlenghi

Tatiana Zollner

Giuseppe Rossi

Chiara Pagani

Chiara Cattaneo

Michele Malagola

Alessandra Sottini

Diego Bertoli

Mariella Tonelli

Marco Chiarini

Rossella Leopaldo

Angela Passi

Lorenzo Masina

Francesca Federico

Carlotta Giupponi

Alessandra Tucci

Affiliations

Soon will be listed here.

References

Ribera J, Garcia O, Gil C, Mercadal S, Garcia-Cadenas I, Montesinos P . Comparison of intensive, pediatric-inspired therapy with non-intensive therapy in older adults aged 55-65 years with Philadelphia chromosome-negative acute lymphoblastic leukemia. Leuk Res. 2018; 68:79-84. DOI: 10.1016/j.leukres.2018.03.010. View

Guru Murthy G, Venkitachalam R, Mehta P . Trends in survival outcomes of B-lineage acute lymphoblastic leukemia in elderly patients: analysis of Surveillance, Epidemiology, and End Results database. Leuk Lymphoma. 2014; 56(8):2296-300. DOI: 10.3109/10428194.2014.991921. View

van Dongen J, Langerak A, Bruggemann M, Evans P, Hummel M, Lavender F . Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003; 17(12):2257-317. DOI: 10.1038/sj.leu.2403202. View

Ferrara F, Barosi G, Venditti A, Angelucci E, Gobbi M, Pane F . Consensus-based definition of unfitness to intensive and non-intensive chemotherapy in acute myeloid leukemia: a project of SIE, SIES and GITMO group on a new tool for therapy decision making. Leukemia. 2013; 27(5):997-9. DOI: 10.1038/leu.2012.303. View

Jabbour E, Short N, Senapati J, Jain N, Huang X, Daver N . Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: long-term results of an open-label phase 2 trial. Lancet Haematol. 2023; 10(6):e433-e444. PMC: 11840755. DOI: 10.1016/S2352-3026(23)00073-X. View

Tucci A, Ferrari S, Bottelli C, Borlenghi E, Drera M, Rossi G . A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy. Cancer. 2009; 115(19):4547-53. DOI: 10.1002/cncr.24490. View

Bassan R, Pavoni C, Intermesoli T, Spinelli O, Tosi M, Audisio E . Updated risk-oriented strategy for acute lymphoblastic leukemia in adult patients 18-65 years: NILG ALL 10/07. Blood Cancer J. 2020; 10(11):119. PMC: 7666128. DOI: 10.1038/s41408-020-00383-2. View

Kozlowski P, Lennmyr E, Ahlberg L, Bernell P, Hulegardh E, Karbach H . Age but not Philadelphia positivity impairs outcome in older/elderly patients with acute lymphoblastic leukemia in Sweden. Eur J Haematol. 2017; 99(2):141-149. DOI: 10.1111/ejh.12896. View

Salas M, Atenafu E, Pasic I, Al-Shaibani E, Bascom O, Wilson L . Impact of hematopoietic cell transplant frailty scale on transplant outcome in adults. Bone Marrow Transplant. 2022; 58(3):317-324. DOI: 10.1038/s41409-022-01892-3. View

10.

Bassan R, Spinelli O, Oldani E, Intermesoli T, Tosi M, Peruta B . Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL). Blood. 2009; 113(18):4153-62. DOI: 10.1182/blood-2008-11-185132. View

11.

Gokbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A . Management of ALL in adults: 2024 ELN recommendations from a European expert panel. Blood. 2024; 143(19):1903-1930. DOI: 10.1182/blood.2023023568. View

12.

Wenge D, Wethmar K, Klar C, Kolve H, Sauer T, Angenendt L . Characteristics and Outcome of Elderly Patients (>55 Years) with Acute Lymphoblastic Leukemia. Cancers (Basel). 2022; 14(3). PMC: 8833618. DOI: 10.3390/cancers14030565. View

13.

Miller K, Al-Kali A, Shah M, Hogan W, Elliott M, Begna K . Elderly acute lymphoblastic leukemia: a Mayo Clinic study of 124 patients. Leuk Lymphoma. 2018; 60(4):990-999. DOI: 10.1080/10428194.2018.1509318. View

14.

Aldoss I, Forman S, Pullarkat V . Acute Lymphoblastic Leukemia in the Older Adult. J Oncol Pract. 2019; 15(2):67-75. DOI: 10.1200/JOP.18.00271. View

15.

van der Velden V, Cazzaniga G, Schrauder A, Hancock J, Bader P, Panzer-Grumayer E . Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data. Leukemia. 2007; 21(4):604-11. DOI: 10.1038/sj.leu.2404586. View

16.

Giebel S, Labopin M, Houhou M, Caillot D, Finke J, Blaise D . Autologous versus allogeneic hematopoietic cell transplantation for older patients with acute lymphoblastic leukemia. An analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant. 2023; 58(4):393-400. DOI: 10.1038/s41409-022-01904-2. View