Clinical Characteristics and Bloodstream Infection Pathogens by Gram-negative Bacteria in Different Aged Adults: A Retrospective Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2024 Nov 13

PMID 39533568

Authors

Li Su

Yawen Cao

Yaomin Liu

Jianhua Zhang

Guomin Zhang

Affiliations

Soon will be listed here.

Abstract

This study aims to determine the characteristics and distribution of pathogenic bacteria in bloodstream infections (BSIs) by gram-negative bacteria in adults. One hundred seventy-one adult patients with BSIs who were treated at the Affiliated Hospital of Chengde Medical College between January 2018 and January 2020 were included in this study. The patients were assigned to the young- and middle-aged group and elderly group based on age. General patient data were analyzed. More elderly patients had BSIs and gram-negative bacteria than young- and middle-aged patients. The incidence of underlying diseases in elderly patients was significantly higher than the young- and middle-aged patients (P < .01). The composition of Brucella spp. was significantly different between the elderly group and young- and middle-aged group (P < .05). There were significantly more gallbladder infections in the elderly group than the young- and middle-aged group, and significantly fewer elderly patients had no definite infection sites than the young- and middle-aged group (P < .05). The incidence of complications and in-hospital mortality in the elderly group was higher than the young- and middle-aged group (P < .05). BSIs caused by gram-negative bacteria mainly involved elderly patients. BSIs were characterized by complications and a poor prognosis, as well as pathogenic bacteria and primary infection sites.

References

Sousa A, Perez-Rodriguez M, Suarez M, Val N, Martinez-Lamas L, Nodar A . Short- versus long-course therapy in gram-negative bacilli bloodstream infections. Eur J Clin Microbiol Infect Dis. 2019; 38(5):851-857. DOI: 10.1007/s10096-019-03467-5. View

Wang W, Jiang T, Zhang W, Li C, Chen J, Xiang D . Predictors of mortality in bloodstream infections caused by multidrug-resistant gram-negative bacteria: 4 years of collection. Am J Infect Control. 2016; 45(1):59-64. DOI: 10.1016/j.ajic.2016.08.008. View

Leibovici-Weissman Y, Tau N, Yahav D . Bloodstream infections in the elderly: what is the real goal?. Aging Clin Exp Res. 2019; 33(4):1101-1112. DOI: 10.1007/s40520-019-01337-w. View

Qu J, Yuan H, Huang Y, Qu Q, Ou-Yang Z, Li G . Evaluation of neutrophil-lymphocyte ratio in predicting bloodstream infection. Biomark Med. 2019; 13(15):1255-1261. DOI: 10.2217/bmm-2018-0253. View

Tang Y, Su Y, Cao Q, Gao Y . Microbiologically Documented Bloodstream Infection in Children With Malignancies: A Single-center Experience. J Pediatr Hematol Oncol. 2020; 42(7):e558-e562. DOI: 10.1097/MPH.0000000000001768. View

Jiang Z, Wang S, Feng D, Zhang B, Mao S, Wu J . Epidemiological risk factors for nosocomial bloodstream infections: A four-year retrospective study in China. J Crit Care. 2019; 52:92-96. DOI: 10.1016/j.jcrc.2019.04.019. View

Yao J, Li N, Jiang J . Clinical Characteristics of Bloodstream Infections in Pediatric Acute Leukemia: A Single-center Experience with 231 Patients. Chin Med J (Engl). 2017; 130(17):2076-2081. PMC: 5586176. DOI: 10.4103/0366-6999.213411. View

Cheng S, Xu S, Guo J, He Q, Li A, Huang L . Risk Factors of Central Venous Catheter-Related Bloodstream Infection for Continuous Renal Replacement Therapy in Kidney Intensive Care Unit Patients. Blood Purif. 2018; 48(2):175-182. DOI: 10.1159/000495024. View

Shimon O, Green H, Eliakim-Raz N, Rozen-Zvi B, Ben-Zvi H, Zohar I . Gram-negative bloodstream infections in hemodialysis patients: A retrospective study . Clin Nephrol. 2018; 90(2):117-124. DOI: 10.5414/CN109172. View

10.

Descours G, Desmurs L, Hoang T, Ibranosyan M, Baume M, Ranc A . Evaluation of the Accelerate Pheno™ system for rapid identification and antimicrobial susceptibility testing of Gram-negative bacteria in bloodstream infections. Eur J Clin Microbiol Infect Dis. 2018; 37(8):1573-1583. DOI: 10.1007/s10096-018-3287-6. View

11.

Ronkko R, Juutilainen A, Koivula I, Vanska M, Nousiainen T, Jantunen E . Changes in the microbiological epidemiology of febrile neutropenia in autologous stem cell transplant recipients. Infect Dis (Lond). 2018; 50(6):436-442. DOI: 10.1080/23744235.2017.1420221. View

12.

Jagtap P, Singh R, Deepika K, Sritharan V, Gupta S . A Flowthrough Assay for Rapid Bedside Stratification of Bloodstream Bacterial Infection in Critically Ill Patients: a Pilot Study. J Clin Microbiol. 2018; 56(9). PMC: 6113456. DOI: 10.1128/JCM.00408-18. View

13.

Yahav D, Schlesinger A, Shaked H, Goldberg E, Paul M, Bishara J . Clinical presentation, management and outcomes of Staph aureus bacteremia (SAB) in older adults. Aging Clin Exp Res. 2016; 29(2):127-133. DOI: 10.1007/s40520-016-0543-4. View

14.

Pourakbari B, Mahmoudi S, Moradzadeh M, Mahzari M, Haghi Ashtiani M, Tanzifi P . Antimicrobial Resistance Patterns of the Gram-positive Bacteria Isolated from Children with Bloodstream Infection in an Iranian Referral Hospital: A 6-year Study. Infect Disord Drug Targets. 2017; 18(2):136-144. DOI: 10.2174/1871526517666170821164343. View

15.

Surapat B, Montakantikul P, Malathum K, Kiertiburanakul S, Santanirand P, Chindavijak B . Microbial epidemiology and risk factors for relapse in gram-negative bacteria catheter-related bloodstream infection with a pilot prospective study in patients with catheter removal receiving short-duration of antibiotic therapy. BMC Infect Dis. 2020; 20(1):604. PMC: 7430115. DOI: 10.1186/s12879-020-05312-z. View

16.

Buetti N, Atkinson A, Marschall J, Kronenberg A . Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008-2014. BMJ Open. 2017; 7(3):e013665. PMC: 5372113. DOI: 10.1136/bmjopen-2016-013665. View

17.

Lodise T, Kanakamedala H, Hsu W, Cai B . Impact of Incremental Delays in Appropriate Therapy on the Outcomes of Hospitalized Adult Patients with Gram-negative Bloodstream Infections: "Every day matters". Pharmacotherapy. 2020; 40(9):889-901. DOI: 10.1002/phar.2446. View

18.

Payeras A, Garcia-Gasalla M, Garau M, Juan I Roca M, Pareja A, Cifuentes C . [Bacteremia in very elderly patients: risk factors, clinical characteristics and mortality]. Enferm Infecc Microbiol Clin. 2007; 25(10):612-8. DOI: 10.1157/13112936. View

19.

Eichenberger E, Dagher M, Ruffin F, Park L, Hersh L, Sivapalasingam S . Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria. Eur J Clin Microbiol Infect Dis. 2020; 39(11):2121-2131. PMC: 7334117. DOI: 10.1007/s10096-020-03955-z. View

20.

Yang X, Cheng X, Tang Y, Qiu X, Wang Z, Fu G . The role of type 1 interferons in coagulation induced by gram-negative bacteria. Blood. 2020; 135(14):1087-1100. PMC: 7118812. DOI: 10.1182/blood.2019002282. View