Association Between Urinary Sodium-to-potassium Ratio, Elevated Blood Pressure Phenotypes and Microalbuminuria: Tehran Lipid and Glucose Study

This cross-sectional study investigated the associations between urinary sodium (UNa) to potassium (UK) ratio, different phenotypes of elevated blood pressure (BP), and microalbuminuria (MAU) in a cohort of the Tehran Lipid and Glucose Study (TLGS). Adult participants (n = 1782, mean age of 43.0 ± 13.7 years and 46.0% were men) were recruited (2015-2017) for measurements of spot urinary metabolites, i.e., Na, K, creatinine (Cr), microalbumin, and BP. Multinomial logistic regression was used to estimate the relative risk ratios (RRR) of elevated BP phenotypes [i.e., isolated systolic (ISH), diastolic (IDH), and systolic-diastolic (SDH) hypertension], and binary logistic regression was used to estimate odds ratios (ORs) of MAU across quintile categories and per each SD-increment of UNa-K ratio. Mean UNa, UK, and its ratio was 137 ± 57.4, 72.1 ± 36.6 mmol/L, and 2.31 ± 1.41, respectively. Subjects with UNa-K > 3.14 had higher prevalence of ISH (3.4 vs. 1.1%), SDH (11.0 vs. 6.2%), and MAU (14.1 vs. 6.2%) (P for all < 0.05). Highest compared to the lowest UNa-K ratio values (> 3.14 vs. <1.23) was associated with an increased probability of SDH (RRR = 1.79, 95% CI 1.09-3.19) and MAU (OR = 2.53, 95% CI 1.23-5.20). Every 1 SD-increment of the UNa-K ratio was associated with a 29 and 38% increased chance of having SDH and MAU, respectively. Our findings imply that a high UNa-K ratio may be a potential risk factor for elevated BP and renal dysfunction.