Weighted Vest Intervention During Whole-body Circuit Training Improves Serum Resistin, Insulin Resistance, and Cardiometabolic Risk Factors in Normal-weight Obese Women

Overview

Journal J Exerc Sci Fit

Date 2024 Nov 11

PMID 39525516

Authors

Jiwoong Kim

Eunsook Kim

Dohyun Kim

Sungjin Yoon

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Obesity is a well-known cause of cardiovascular disease and metabolic disorders. Normal-weight obesity, where the body mass index(BMI) is within the normal range but the body fat percentage is high, also adversely impacts cardiovascular and metabolic health. This study explored the effects of whole-body circuit training using a weighted vest on serum resistin, insulin resistance, and cardiovascular disease risk factors in normal-weight obese women.

Methods: Thirty-six normal-weight obese women were divided into three groups: Weighted Vest Circuit Training(WVCT)(n = 12), Body Weight Circuit Training(BWCT)(n = 12), and a Control group(CON)(n = 12). Participants in the WVCT and BWCT groups engaged in whole-body circuit training three times per week for eight weeks. Serum resistin, cardiovascular disease risk factors, and insulin resistance were measured before and after the intervention.

Results: The study revealed significant and impactful findings. There were substantial improvements in body composition(Skeletal Muscle Mass: +7.5 %, = 0.042, = 0.80), Serum Resistin(-38.2 %, = 0.001, = 0.85), insulin resistance(HOMA-IR: 27.1 %, < 0.001, = 0.88), and a reduction in IL-6 levels(-25.4 %, = 0.082, = 0.60) in the WVCT group compared to the BWCT and CON groups. The WVCT group outperformed the other groups, demonstrating greater effectiveness in reducing cardiovascular risk factors.

Conclusion: These findings have significant implications for healthcare. Whole-body circuit training with weighted vests has effectively improved body composition, reduced serum resistin, and lowered insulin resistance, reducing cardiovascular disease risk factors in normal-weight obese women. These results could inform and enhance the treatment and management of obesity-related cardiovascular and metabolic disorders.

References

Juffer P, Bakker A, Klein-Nulend J, Jaspers R . Mechanical loading by fluid shear stress of myotube glycocalyx stimulates growth factor expression and nitric oxide production. Cell Biochem Biophys. 2014; 69(3):411-9. DOI: 10.1007/s12013-013-9812-4. View

Ridker P, Rifai N, Pfeffer M, Sacks F, Braunwald E . Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation. 1999; 100(3):230-5. DOI: 10.1161/01.cir.100.3.230. View

Merz K, Thurmond D . Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake. Compr Physiol. 2020; 10(3):785-809. PMC: 8074531. DOI: 10.1002/cphy.c190029. View

Kim S, Kyung C, Park J, Lee S, Kim H, Ahn C . Normal-weight obesity is associated with increased risk of subclinical atherosclerosis. Cardiovasc Diabetol. 2015; 14:58. PMC: 4488951. DOI: 10.1186/s12933-015-0220-5. View

Martins F, de Paula Souza A, Nunes P, Michelin M, Murta E, Resende E . High-intensity body weight training is comparable to combined training in changes in muscle mass, physical performance, inflammatory markers and metabolic health in postmenopausal women at high risk for type 2 diabetes mellitus: A randomized.... Exp Gerontol. 2018; 107:108-115. DOI: 10.1016/j.exger.2018.02.016. View

Juffer P, Jaspers R, Lips P, Bakker A, Klein-Nulend J . Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes. Am J Physiol Endocrinol Metab. 2011; 302(4):E389-95. DOI: 10.1152/ajpendo.00320.2011. View

Ho S, Dhaliwal S, Hills A, Pal S . The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial. BMC Public Health. 2012; 12:704. PMC: 3487794. DOI: 10.1186/1471-2458-12-704. View

Romero-Corral A, Somers V, Sierra-Johnson J, Korenfeld Y, Boarin S, Korinek J . Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2009; 31(6):737-46. PMC: 2838679. DOI: 10.1093/eurheartj/ehp487. View

Lee E, Seo T, Kim Y . Effect of resistance circuit training on health-related physical fitness, plasma lipid, and adiponectin in obese college students. J Exerc Rehabil. 2023; 18(6):382-388. PMC: 9816610. DOI: 10.12965/jer.2244402.201. View

10.

Iversen V, Norum M, Schoenfeld B, Fimland M . No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review. Sports Med. 2021; 51(10):2079-2095. PMC: 8449772. DOI: 10.1007/s40279-021-01490-1. View

11.

McInnis K, Balady G . Comparison of submaximal exercise responses using the Bruce vs modified Bruce protocols. Med Sci Sports Exerc. 1994; 26(1):103-7. View

12.

Daval M, Foufelle F, Ferre P . Functions of AMP-activated protein kinase in adipose tissue. J Physiol. 2006; 574(Pt 1):55-62. PMC: 1817807. DOI: 10.1113/jphysiol.2006.111484. View

13.

Oda E . LDL cholesterol was more strongly associated with percent body fat than body mass index and waist circumference in a health screening population. Obes Res Clin Pract. 2017; 12(2):195-203. DOI: 10.1016/j.orcp.2017.05.005. View

14.

Rusko H, Bosco C . Metabolic response of endurance athletes to training with added load. Eur J Appl Physiol Occup Physiol. 1987; 56(4):412-8. DOI: 10.1007/BF00417768. View

15.

Klop B, Elte J, Cabezas M . Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013; 5(4):1218-40. PMC: 3705344. DOI: 10.3390/nu5041218. View

16.

Kim J, Ko Y, Seo T, Kim Y . Effect of circuit training on body composition, physical fitness, and metabolic syndrome risk factors in obese female college students. J Exerc Rehabil. 2018; 14(3):460-465. PMC: 6028228. DOI: 10.12965/jer.1836194.097. View

17.

Zanchi N, Lancha Jr A . Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k and protein synthesis. Eur J Appl Physiol. 2007; 102(3):253-63. DOI: 10.1007/s00421-007-0588-3. View

18.

Gomez-Zorita S, Queralt M, Vicente M, Gonzalez M, Portillo M . Metabolically healthy obesity and metabolically obese normal weight: a review. J Physiol Biochem. 2021; 77(1):175-189. DOI: 10.1007/s13105-020-00781-x. View

19.

Kim M, Han K, Kwon H, Song K, Yim H, Lee W . Normal weight obesity in Korean adults. Clin Endocrinol (Oxf). 2013; 80(2):214-20. DOI: 10.1111/cen.12162. View

20.

Fuchs F, Whelton P . High Blood Pressure and Cardiovascular Disease. Hypertension. 2019; 75(2):285-292. PMC: 10243231. DOI: 10.1161/HYPERTENSIONAHA.119.14240. View