Deep Tissue Photoacoustic Imaging with Light and Sound

Overview

Journal Npj Imaging

Date 2024 Nov 11

PMID 39525280

Authors

Luca Menozzi

Junjie Yao

Affiliations

Soon will be listed here.

Abstract

Photoacoustic computed tomography (PACT) can harvest diffusive photons to image the optical absorption contrast of molecules in a scattering medium, with ultrasonically-defined spatial resolution. PACT has been extensively used in preclinical research for imaging functional and molecular information in various animal models, with recent clinical translations. In this review, we aim to highlight the recent technical breakthroughs in PACT and the emerging preclinical and clinical applications in deep tissue imaging.

References

Xiang L, Wang B, Ji L, Jiang H . 4-D photoacoustic tomography. Sci Rep. 2013; 3:1113. PMC: 3552346. DOI: 10.1038/srep01113. View

Choi W, Park E, Jeon S, Kim C . Clinical photoacoustic imaging platforms. Biomed Eng Lett. 2019; 8(2):139-155. PMC: 6208525. DOI: 10.1007/s13534-018-0062-7. View

Li M, Tang Y, Yao J . Photoacoustic tomography of blood oxygenation: A mini review. Photoacoustics. 2018; 10:65-73. PMC: 6033062. DOI: 10.1016/j.pacs.2018.05.001. View

Zhang E, Laufer J, Beard P . Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues. Appl Opt. 2008; 47(4):561-77. DOI: 10.1364/ao.47.000561. View

Liu Y, Bhattarai P, Dai Z, Chen X . Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2018; 48(7):2053-2108. PMC: 6437026. DOI: 10.1039/c8cs00618k. View

Park H, Yao J, Jing Y . A frequency-domain model-based reconstruction method for transcranial photoacoustic imaging: A 2D numerical investigation. Photoacoustics. 2023; 33:100561. PMC: 10658607. DOI: 10.1016/j.pacs.2023.100561. View

Miri Rostami S, Mozaffarzadeh M, Ghaffari-Miab M, Hariri A, Jokerst J . GPU-accelerated Double-stage Delay-multiply-and-sum Algorithm for Fast Photoacoustic Tomography Using LED Excitation and Linear Arrays. Ultrason Imaging. 2019; 41(5):301-316. DOI: 10.1177/0161734619862488. View

Agrawal S, Fadden C, Dangi A, Yang X, Albahrani H, Frings N . Light-Emitting-Diode-Based Multispectral Photoacoustic Computed Tomography System. Sensors (Basel). 2019; 19(22). PMC: 6891584. DOI: 10.3390/s19224861. View

Cupil-Garcia V, Li J, Norton S, Odion R, Strobbia P, Menozzi L . Plasmonic nanorod probes' journey inside plant cells for SERS sensing and multimodal imaging. Nanoscale. 2023; 15(13):6396-6407. DOI: 10.1039/d2nr06235f. View

10.

Fatima A, Kratkiewicz K, Manwar R, Zafar M, Zhang R, Huang B . Review of cost reduction methods in photoacoustic computed tomography. Photoacoustics. 2019; 15:100137. PMC: 6693691. DOI: 10.1016/j.pacs.2019.100137. View

11.

Li H, Dong B, Zhang Z, Zhang H, Sun C . A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy. Sci Rep. 2014; 4:4496. PMC: 3968454. DOI: 10.1038/srep04496. View

12.

Li L, Zhu L, Ma C, Lin L, Yao J, Wang L . Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution. Nat Biomed Eng. 2018; 1(5). PMC: 5766044. DOI: 10.1038/s41551-017-0071. View

13.

Ding L, Razansky D, Dean-Ben X . Model-Based Reconstruction of Large Three-Dimensional Optoacoustic Datasets. IEEE Trans Med Imaging. 2020; 39(9):2931-2940. DOI: 10.1109/TMI.2020.2981835. View

14.

Rong Q, Lee Y, Tang Y, Vu T, Taboada C, Zheng W . High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator. BME Front. 2023; 2022. PMC: 9933894. DOI: 10.34133/2022/9891510. View

15.

Zheng W, Huang C, Zhang H, Xia J . Slit-based photoacoustic tomography with co-planar light illumination and acoustic detection for high-resolution vascular imaging in human using a linear transducer array. Biomed Eng Lett. 2022; 12(2):125-133. PMC: 9046509. DOI: 10.1007/s13534-022-00224-0. View

16.

Li Y, Li L, Zhu L, Maslov K, Shi J, Hu P . Snapshot Photoacoustic Topography Through an Ergodic Relay for High-throughput Imaging of Optical Absorption. Nat Photonics. 2021; 14(3):164-170. PMC: 8223468. DOI: 10.1038/s41566-019-0576-2. View

17.

Park S, Brooks F, Villa U, Su R, Anastasio M, Oraevsky A . Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast. J Biomed Opt. 2022; 27(3). PMC: 8923705. DOI: 10.1117/1.JBO.27.3.036001. View

18.

Zhu L, Cao H, Ma J, Wang L . Optical ultrasound sensors for photoacoustic imaging: a review. J Biomed Opt. 2024; 29(Suppl 1):S11523. PMC: 10831871. DOI: 10.1117/1.JBO.29.S1.S11523. View

19.

Li L, Li Y, Zhang Y, Wang L . Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo. Nat Protoc. 2021; 16(5):2381-2394. PMC: 8186536. DOI: 10.1038/s41596-020-00487-w. View

20.

Beard P . Biomedical photoacoustic imaging. Interface Focus. 2012; 1(4):602-31. PMC: 3262268. DOI: 10.1098/rsfs.2011.0028. View