Exploring the Protective Effect of Silver Nano-extract Against Azoxymethane Induced Toxicity in Female Reproductive Organs in Rats

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Nov 11

PMID 39524721

Authors

Wael Mahmoud Aboulthana

Abd El-Nasser A Madboli

Amal Gouda Hussien

Mohamed Seif

Affiliations

Soon will be listed here.

Abstract

Reproductive toxicity from food and environmental contaminants has greatly affected human life. Plants are a fundamental source of bioactive components for relieving the harmful effects of pollutants. Hydrazine metabolites pose health threats when they enter the food chain. () exhibits anti-inflammatory and anti-tumor properties. Silver nanoparticles enhance the chemical stability of . Reproductive toxicity of Azoxymethane (AOM) and anticancer effects of silver were evaluated. Thirty-six adult female rats were divided into six groups () and treated with AOM with or without silver nano-extract as pre- and post-treatment. Sexual hormones and proteins were assessed under silver nano-extract and AOM. Histopathologically, AOM caused metaplastic myometrial endometriotic cysts and endometrial metaplasia. Silver in pre- and post-treated rats mitigated the carcinogenic effects of AOM. Immunohistochemically, AOM carcinogenicity was evident through moderate detection of the CK-7 tumor marker in the ovaries and uterus of the AOM-, simultaneous-, and post-treated groups. ameliorated this, with CK-7 slightly expressed in the pre-treated group. Furthermore, alleviated the negative impact on FSH, LH, and 17-β estradiol hormones. In conclusion, Silver nano-extract successfully prevented tumors in the ovaries and uterus of AOM-treated rats.

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