Exhalation Metabolomics: A New Force in Revealing the Impact of Ozone Pollution on Respiratory Health

Overview

Journal Eco Environ Health

Date 2024 Nov 11

PMID 39524475

Authors

Chen Tao

Peter Mettke

Yaru Wang

Xue Li

Ligang Hu

Affiliations

Soon will be listed here.

Abstract

Image 1.

Citing Articles

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References

Zanella D, Henket M, Schleich F, Dejong T, Louis R, Focant J . Comparison of the effect of chemically and biologically induced inflammation on the volatile metabolite production of lung epithelial cells by GC×GC-TOFMS. Analyst. 2020; 145(15):5148-5157. DOI: 10.1039/d0an00720j. View

Min S, Bin W, Sihua L, Bin Y, Ming W . Effects of Beijing Olympics control measures on reducing reactive hydrocarbon species. Environ Sci Technol. 2010; 45(2):514-9. DOI: 10.1021/es102357t. View

. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020; 396(10258):1223-1249. PMC: 7566194. DOI: 10.1016/S0140-6736(20)30752-2. View

Sun N, Niu Y, Zhang R, Huang Y, Wang J, Qiu W . Ozone inhalation induces exacerbation of eosinophilic airway inflammation and Th2-skew immune response in a rat model of AR. Biomed Pharmacother. 2021; 137:111261. DOI: 10.1016/j.biopha.2021.111261. View

Wright J, Konwar K, Hallam S . Microbial ecology of expanding oxygen minimum zones. Nat Rev Microbiol. 2012; 10(6):381-94. DOI: 10.1038/nrmicro2778. View

Crouse D, Peters P, Hystad P, Brook J, van Donkelaar A, Martin R . Ambient PM2.5, O₃, and NO₂ Exposures and Associations with Mortality over 16 Years of Follow-Up in the Canadian Census Health and Environment Cohort (CanCHEC). Environ Health Perspect. 2015; 123(11):1180-6. PMC: 4629747. DOI: 10.1289/ehp.1409276. View

Xing Q, Zhang L, Liu H, Zhu C, Yao M . Exhaled VOC Biomarkers from Rats Injected with PMs from Thirty-One Major Cities in China. Environ Sci Technol. 2023; 57(49):20510-20520. DOI: 10.1021/acs.est.3c06074. View

Martin C, Burgel P, Lepage P, Andrejak C, De Blic J, Bourdin A . Host-microbe interactions in distal airways: relevance to chronic airway diseases. Eur Respir Rev. 2015; 24(135):78-91. PMC: 9487770. DOI: 10.1183/09059180.00011614. View

Huang Q, Hu D, Wang X, Chen Y, Wu Y, Pan L . The modification of indoor PM exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis. Environ Int. 2018; 121(Pt 2):1243-1252. DOI: 10.1016/j.envint.2018.10.046. View

10.

Pasamontes A, Aksenov A, Schivo M, Rowles T, Smith C, Schwacke L . Noninvasive Respiratory Metabolite Analysis Associated with Clinical Disease in Cetaceans: A Deepwater Horizon Oil Spill Study. Environ Sci Technol. 2017; 51(10):5737-5746. DOI: 10.1021/acs.est.6b06482. View

11.

Wang T, Xue L, Brimblecombe P, Lam Y, Li L, Zhang L . Ozone pollution in China: A review of concentrations, meteorological influences, chemical precursors, and effects. Sci Total Environ. 2016; 575:1582-1596. DOI: 10.1016/j.scitotenv.2016.10.081. View

12.

Mu L, Niu Z, Hageman Blair R, Yu H, Browne R, Bonner M . Metabolomics Profiling before, during, and after the Beijing Olympics: A Panel Study of Within-Individual Differences during Periods of High and Low Air Pollution. Environ Health Perspect. 2019; 127(5):57010. PMC: 6791568. DOI: 10.1289/EHP3705. View

13.

Schuijt T, Lankelma J, Scicluna B, de Sousa E Melo F, Roelofs J, de Boer J . The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut. 2015; 65(4):575-83. PMC: 4819612. DOI: 10.1136/gutjnl-2015-309728. View

14.

Garcia-Gomez D, Bregy L, Nussbaumer-Ochsner Y, Gaisl T, Kohler M, Zenobi R . Detection and Quantification of Benzothiazoles in Exhaled Breath and Exhaled Breath Condensate by Real-Time Secondary Electrospray Ionization-High-Resolution Mass Spectrometry and Ultra-High Performance Liquid Chromatography. Environ Sci Technol. 2015; 49(20):12519-24. DOI: 10.1021/acs.est.5b03809. View

15.

Dickson R, Singer B, Newstead M, Falkowski N, Erb-Downward J, Standiford T . Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbiol. 2016; 1(10):16113. PMC: 5076472. DOI: 10.1038/nmicrobiol.2016.113. View

16.

Lu C, Mao J, Wang L, Guan Z, Zhao G, Li M . An unusual high ozone event over the North and Northeast China during the record-breaking summer in 2018. J Environ Sci (China). 2021; 104:264-276. DOI: 10.1016/j.jes.2020.11.030. View

17.

Zhu X, Zhang Q, Du X, Jiang Y, Niu Y, Wei Y . Respiratory Effects of Traffic-Related Air Pollution: A Randomized, Crossover Analysis of Lung Function, Airway Metabolome, and Biomarkers of Airway Injury. Environ Health Perspect. 2023; 131(5):57002. PMC: 10159268. DOI: 10.1289/EHP11139. View

18.

Yao M, Hu Y, Zhang A, Ji J, Zhao B . COPD deaths attributable to ozone in 2019 and future projections using the WHO AQG 2021 in urban China. Eco Environ Health. 2023; 1(4):251-258. PMC: 10702908. DOI: 10.1016/j.eehl.2022.11.002. View

19.

Neyrinck A, Rodriguez J, Zhang Z, Nazare J, Bindels L, Cani P . Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers. EBioMedicine. 2022; 80:104051. PMC: 9108873. DOI: 10.1016/j.ebiom.2022.104051. View

20.

Kallet R, Matthay M . Hyperoxic acute lung injury. Respir Care. 2012; 58(1):123-41. PMC: 3915523. DOI: 10.4187/respcare.01963. View