Serotonin Acts Through Multiple Cellular Targets During an Olfactory Critical Period

Overview

Journal iScience

Publisher Cell Press

Date 2024 Nov 11

PMID 39524339

Authors

Ahana Mallick

Hua Leonhard Tan

Jacob Michael Epstein

Clarissa Mei Jing Ng

Oliver Mason Cook

Quentin Gaudry

Andrew M Dacks

Affiliations

Soon will be listed here.

Abstract

Serotonin (5-HT) modulates early development during critical periods when experience drives heightened levels of plasticity in neurons. Here, we investigate the cellular mechanisms by which 5-HT modulates critical period plasticity (CPP) in the olfactory system of . We first demonstrate that 5-HT is necessary for experience-dependent structural plasticity in response to chronic CO exposure and can re-open the critical period long after it normally closes. Knocking down 5-HT7 receptors in a subset of GABAergic local interneurons was sufficient to block CPP, as was knocking down GABA receptors expressed by CO-sensing olfactory sensory neurons (OSNs). Furthermore, direct modulation of OSNs via 5-HT2B receptors in CO-sensing OSNs and autoreceptor expression by serotonergic neurons was also required for CPP. Thus, 5-HT targets individual neuron types in the olfactory system via distinct receptors to enable sensory driven plasticity.

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