Static and Dynamic Functional Network Connectivity In Parkinson's Disease Patients With Postural Instability And Gait Disorder

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2024 Nov 10

PMID 39523453

Authors

Bo Shen

Qun Yao

Yixuan Zhang

Yinyin Jiang

Yaxi Wang

Xu Jiang

Yang Zhao

Haiying Zhang

Shuangshuang Dong

Dongfeng Li

Yaning Chen

Yang Pan

Jun Yan

Feng Han

Shengrong Li

Qi Zhu

Daoqiang Zhang

Li Zhang

Yun-Cheng Wu

Affiliations

Soon will be listed here.

Abstract

Aims: The exact cause of the parkinsonism gait remains uncertain. We first focus on understanding the underlying neurological reasons for these symptoms through the examination of both static functional network connectivity (SFNC) and dynamic functional network connectivity (DFNC).

Methods: We recruited 64 postural instability and gait disorder-dominated Parkinson's disease (PIGD-PD) patients, 31 non-PIGD-PD (nPIGD-PD) patients, and 54 healthy controls (HC) from Nanjing Brain Hospital. The GIFT software identified five distinct independent components: the basal ganglia (BG), cerebellum (CB), sensory networks (SMN), default mode network (DMN), and central executive network (CEN). We conducted a comparison between the SFNC and DFNC of the five networks and analyzed their correlations with postural instability and gait disorder (PIGD) symptoms.

Results: Compared with nPIGD-PD patients, the PIGD-PD patients demonstrated reduced connectivity between CEN and DMN while spending less mean dwell time (MDT) in state 4. This is characterized by strong connections. Compared with HC, PIGD-PD patients exhibited enhanced connectivity in the SFNC between CB and CEN, as well as the network between CB and DMN. Patients with PIGD-PD spent more MDT in state 1, which is characterized by few connections, and less MDT in state 4. In state 3, there was an increase in the functional connectivity between the CB and DMN in patients with PIGD-PD. The nPIGD patients showed increased SFNC connectivity between CB and DMN compared to HC. These patients spent more MDT in state 1 and less in state 4. The MDT and fractional windows of state 2 showed a positive link with PIGD scores.

Conclusion: Patients with PIGD-PD exhibit a higher likelihood of experiencing reduced brain connectivity and impaired information processing. The enhanced connection between the cerebellum and DMN networks is considered a type of dynamic compensation.

References

Wang Q, Yu M, Yan L, Xu J, Wang Y, Zhou G . Aberrant inter-network functional connectivity in drug-naive Parkinson's disease patients with tremor dominant and postural instability and gait difficulty. Front Hum Neurosci. 2023; 17:1100431. PMC: 9934857. DOI: 10.3389/fnhum.2023.1100431. View

Peterson D, Pickett K, Duncan R, Perlmutter J, Earhart G . Brain activity during complex imagined gait tasks in Parkinson disease. Clin Neurophysiol. 2013; 125(5):995-1005. PMC: 3981914. DOI: 10.1016/j.clinph.2013.10.008. View

Raccagni C, Nonnekes J, Bloem B, Peball M, Boehme C, Seppi K . Gait and postural disorders in parkinsonism: a clinical approach. J Neurol. 2019; 267(11):3169-3176. PMC: 7578144. DOI: 10.1007/s00415-019-09382-1. View

Zhao C, Huang W, Feng F, Zhou B, Yao H, Guo Y . Abnormal characterization of dynamic functional connectivity in Alzheimer's disease. Neural Regen Res. 2022; 17(9):2014-2021. PMC: 8848607. DOI: 10.4103/1673-5374.332161. View

Li J, Jin M, Wang L, Qin B, Wang K . MDS clinical diagnostic criteria for Parkinson's disease in China. J Neurol. 2016; 264(3):476-481. DOI: 10.1007/s00415-016-8370-2. View

Xing F, Feng J, Lv L, Liu J, Chen X, Sun J . Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease. Am J Transl Res. 2024; 16(6):2423-2434. PMC: 11236641. DOI: 10.62347/GTVB7800. View

Fu Z, Du Y, Calhoun V . The Dynamic Functional Network Connectivity Analysis Framework. Engineering (Beijing). 2020; 5(2):190-193. PMC: 7265753. DOI: 10.1016/j.eng.2018.10.001. View

Chao-Gan Y, Yu-Feng Z . DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Front Syst Neurosci. 2010; 4:13. PMC: 2889691. DOI: 10.3389/fnsys.2010.00013. View

Zuo L, Piao Y, Li L, Yu S, Guo P, Hu Y . Phenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters. Sci Rep. 2017; 7:44872. PMC: 5362957. DOI: 10.1038/srep44872. View

10.

OCallaghan C, Hornberger M, Balsters J, Halliday G, Lewis S, Shine J . Cerebellar atrophy in Parkinson's disease and its implication for network connectivity. Brain. 2016; 139(Pt 3):845-55. DOI: 10.1093/brain/awv399. View

11.

Tan Z, Zeng Q, Hu X, Di D, Chen L, Lin Z . Altered dynamic functional network connectivity in drug-naïve Parkinson's disease patients with excessive daytime sleepiness. Front Aging Neurosci. 2023; 15:1282962. PMC: 10731041. DOI: 10.3389/fnagi.2023.1282962. View

12.

Allen E, Damaraju E, Plis S, Erhardt E, Eichele T, Calhoun V . Tracking whole-brain connectivity dynamics in the resting state. Cereb Cortex. 2012; 24(3):663-76. PMC: 3920766. DOI: 10.1093/cercor/bhs352. View

13.

Joseph-Shehu E, Ncama B, Mooi N, Mashamba-Thompson T . The use of information and communication technologies to promote healthy lifestyle behaviour: a systematic scoping review. BMJ Open. 2019; 9(10):e029872. PMC: 6830587. DOI: 10.1136/bmjopen-2019-029872. View

14.

Smallwood J, Bernhardt B, Leech R, Bzdok D, Jefferies E, Margulies D . The default mode network in cognition: a topographical perspective. Nat Rev Neurosci. 2021; 22(8):503-513. DOI: 10.1038/s41583-021-00474-4. View

15.

Kleinholdermann U, Wullstein M, Pedrosa D . Prediction of motor Unified Parkinson's Disease Rating Scale scores in patients with Parkinson's disease using surface electromyography. Clin Neurophysiol. 2021; 132(7):1708-1713. DOI: 10.1016/j.clinph.2021.01.031. View

16.

Erhardt E, Rachakonda S, Bedrick E, Allen E, Adali T, Calhoun V . Comparison of multi-subject ICA methods for analysis of fMRI data. Hum Brain Mapp. 2010; 32(12):2075-95. PMC: 3117074. DOI: 10.1002/hbm.21170. View

17.

Tang G, Chen P, Chen G, Zhong S, Gong J, Zhong H . Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI. Psychol Med. 2021; :1-11. DOI: 10.1017/S003329172100009X. View

18.

Kim J, Criaud M, Cho S, Diez-Cirarda M, Mihaescu A, Coakeley S . Abnormal intrinsic brain functional network dynamics in Parkinson's disease. Brain. 2017; 140(11):2955-2967. PMC: 5841202. DOI: 10.1093/brain/awx233. View

19.

Daigle K, Pietrzykowski M, Waters A, Swenson L, Gansler D . Central Executive Network and Executive Function in Patients With Alzheimer's Disease and Healthy Individuals: Meta-Analysis of Structural and Functional MRI. J Neuropsychiatry Clin Neurosci. 2022; 34(3):204-213. DOI: 10.1176/appi.neuropsych.20110279. View

20.

Rahimpour S, Rajkumar S, Hallett M . The Supplementary Motor Complex in Parkinson's Disease. J Mov Disord. 2021; 15(1):21-32. PMC: 8820882. DOI: 10.14802/jmd.21075. View