Mesenchymal Stem Cells Lineage and Their Role in Disease Development

Overview

Journal Mol Med

Publisher Biomed Central

Specialties General Medicine
Molecular Biology

Date 2024 Nov 10

PMID 39523306

Authors

Qi Xu

Wenrun Hou

Baorui Zhao

Peixin Fan

Sheng Wang

Lei Wang

Jinfang Gao

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) are widely dispersed in vivo and are isolated from several tissues, including bone marrow, heart, body fluids, skin, and perinatal tissues. Bone marrow MSCs have a multidirectional differentiation potential, which can be induced to differentiate the medium in a specific direction or by adding specific regulatory factors. MSCs repair damaged tissues through lineage differentiation, and the ex vivo transplantation of bone marrow MSCs can heal injured sites. MSCs have different propensities for lineage differentiation and pathological evolution for different diseases, which are crucial in disease progression. In this study, we describe various lineage analysis methods to explore lineage ontology in vitro and in vivo, elucidate the impact of MSC lineage differentiation on diseases, advance our understanding of the role of MSC differentiation in physiological and pathological states, and explore new targets and ideas associated with disease diagnosis and treatment.

Citing Articles

Nanofibrous Scaffolds' Ability to Induce Mesenchymal Stem Cell Differentiation for Soft Tissue Regenerative Applications.

Pisani S, Evangelista A, Chesi L, Croce S, Avanzini M, Dorati R Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40006052 PMC: 11859969. DOI: 10.3390/ph18020239.

Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health.

Fu M, Yoon K, Ha J, Kang I, Choe W Antioxidants (Basel). 2025; 14(2).

PMID: 40002389 PMC: 11852089. DOI: 10.3390/antiox14020203.

References

Heo J, Choi Y, Kim H, Kim H . Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 2016; 37(1):115-25. PMC: 4687432. DOI: 10.3892/ijmm.2015.2413. View

Jia L, Prabhakaran M, Qin X, Ramakrishna S . Stem cell differentiation on electrospun nanofibrous substrates for vascular tissue engineering. Mater Sci Eng C Mater Biol Appl. 2013; 33(8):4640-50. DOI: 10.1016/j.msec.2013.07.021. View

Stent G . Developmental cell lineage. Int J Dev Biol. 1998; 42(3):237-41. View

Zinyk D, MERCER E, Harris E, Anderson D, Joyner A . Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr Biol. 1998; 8(11):665-8. DOI: 10.1016/s0960-9822(98)70255-6. View

Yang X, Wang Y, Rahman H, Merza Mohammad T, Daei Sorkhabi A, Korsakov S . Expression of proliferation-related genes in BM-MSC-treated ALL cells in hypoxia condition is regulated under the influence of epigenetic factors in-vitro. Med Oncol. 2022; 39(5):88. DOI: 10.1007/s12032-022-01671-6. View

LeBleu V, Taduri G, OConnell J, Teng Y, Cooke V, Woda C . Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013; 19(8):1047-53. PMC: 4067127. DOI: 10.1038/nm.3218. View

Wang F, Tang H, Zhu J, Zhang J . Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018; 27(12):1825-1834. PMC: 6300770. DOI: 10.1177/0963689718795424. View

Lv F, Tuan R, Cheung K, Leung V . Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells. 2014; 32(6):1408-19. DOI: 10.1002/stem.1681. View

Liu K, Tang M, Jin H, Liu Q, He L, Zhu H . Triple-cell lineage tracing by a dual reporter on a single allele. J Biol Chem. 2019; 295(3):690-700. PMC: 6970925. DOI: 10.1074/jbc.RA119.011349. View

10.

Baron C, van Oudenaarden A . Unravelling cellular relationships during development and regeneration using genetic lineage tracing. Nat Rev Mol Cell Biol. 2019; 20(12):753-765. DOI: 10.1038/s41580-019-0186-3. View

11.

Livet J, Weissman T, Kang H, Draft R, Lu J, Bennis R . Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature. 2007; 450(7166):56-62. DOI: 10.1038/nature06293. View

12.

Langenbach F, Handschel J . Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013; 4(5):117. PMC: 3854789. DOI: 10.1186/scrt328. View

13.

Murphy J, Dixon K, Beck S, Fabian D, Feldman A, Barry F . Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum. 2002; 46(3):704-13. DOI: 10.1002/art.10118. View

14.

Bougioukli S, Chateau M, Morales H, Vakhshori V, Sugiyama O, Oakes D . Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. 2020; 28(12):729-739. DOI: 10.1038/s41434-020-0182-4. View

15.

Fattizzo B, Giannotta J, Barcellini W . Mesenchymal Stem Cells in Aplastic Anemia and Myelodysplastic Syndromes: The "Seed and Soil" Crosstalk. Int J Mol Sci. 2020; 21(15). PMC: 7432231. DOI: 10.3390/ijms21155438. View

16.

Shi M, Li Y, Xu R, Meng F, Yu S, Fu J . Mesenchymal stem cell therapy in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized controlled clinical trial. Hepatol Int. 2021; 15(6):1431-1441. PMC: 8651584. DOI: 10.1007/s12072-021-10199-2. View

17.

Lee D, Kiener H, Agarwal S, Noss E, Watts G, Chisaka O . Cadherin-11 in synovial lining formation and pathology in arthritis. Science. 2007; 315(5814):1006-10. DOI: 10.1126/science.1137306. View

18.

Fu X, Liu G, Halim A, Ju Y, Luo Q, Song A . Mesenchymal Stem Cell Migration and Tissue Repair. Cells. 2019; 8(8). PMC: 6721499. DOI: 10.3390/cells8080784. View

19.

Lawson K, Meneses J, Pedersen R . Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development. 1991; 113(3):891-911. DOI: 10.1242/dev.113.3.891. View

20.

Jiang X, Wu F, Xu Y, Yan J, Wu Y, Li S . A novel role of angiotensin II in epidermal cell lineage determination: Angiotensin II promotes the differentiation of mesenchymal stem cells into keratinocytes through the p38 MAPK, JNK and JAK2 signalling pathways. Exp Dermatol. 2018; 28(1):59-65. DOI: 10.1111/exd.13837. View