» Articles » PMID: 39522009

Predictive Haemostatic Biomarkers and Transfusion Efficacy, Insights from Fresh Frozen Plasma Use in Surgical Patients, Preliminary Results

Overview
Journal BMC Res Notes
Publisher Biomed Central
Date 2024 Nov 10
PMID 39522009
Authors
Affiliations
Soon will be listed here.
Abstract

The aim of the study was to examine various haemostasis values to identify the most relevant biological indicators for detecting significant haemorrhage, to determine the effectiveness of fresh frozen plasma (FFP) transfusion. Our findings suggest that a low prothrombin time, elevated Von Willebrand Antigen, increased plasma fibrinogen, and reduced Ca2 + levels are associated with challenges in achieving proper haemostasis. However, measurements of factors II, V, VII, VIII, IX, X, XI, XIII, protein C, and protein S do not appear to be linked to difficulties in achieving adequate haemostasis. Additionally, the administration of FFP appears to impact factors V, VII, X, and II.Trial registration EudraCT number: 2019-002898-64.

References
1.
Davalos D, Akassoglou K . Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2011; 34(1):43-62. DOI: 10.1007/s00281-011-0290-8. View

2.
Kornblith L, Moore H, Cohen M . Trauma-induced coagulopathy: The past, present, and future. J Thromb Haemost. 2019; 17(6):852-862. PMC: 6545123. DOI: 10.1111/jth.14450. View

3.
Hayakawa M . Dynamics of fibrinogen in acute phases of trauma. J Intensive Care. 2021; 5(1):3. PMC: 8600928. DOI: 10.1186/s40560-016-0199-3. View

4.
. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*. Anesthesiology. 2014; 122(2):241-75. DOI: 10.1097/ALN.0000000000000463. View

5.
Luyendyk J, Schoenecker J, Flick M . The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. 2018; 133(6):511-520. PMC: 6367649. DOI: 10.1182/blood-2018-07-818211. View