Efficacy and Safety of Acupuncture for Pain Relief: a Systematic Review and Meta-analysis

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2024 Nov 9

PMID 39520569

Authors

Chu Qin

Huan Ma

Haojie Ni

Minyan Wang

Yun Shi

Oscar Onayi Mandizadza

Lihong Li

Conghua Ji

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to evaluate the efficacy and safety of traditional acupuncture for pain relief based on rigorously designed RCTs with double-blind. The findings seek to provide valuable insights for clinical practice and inform future research.

Methods: A literature search was conducted in PubMed, Web of Science, Cochrane Library, and Embase databases for randomized controlled trials on traditional acupuncture for pain management using a double-blind design, published from database inception to November 22, 2023. The Risk of Bias 2 (RoB2) tool was used to assess potential biases in the included studies, followed by a comprehensive analysis to evaluate efficacy and safety.

Results: The findings show a significant positive effect on pain improvement, evidenced by changes in visual analog scale scores (mean difference 0.97 [95% confidence interval (CI) 0.66-1.27]). Safety analysis showed no significant differences in adverse reactions between the acupuncture and control groups (relative risk 1.40 [95% CI 0.52-3.74]), with no serious adverse effects reported.

Conclusion: Traditional acupuncture is effective and safe in pain management. This suggests that acupuncture can be a valuable approach in clinical practice. Future studies should explore optimal treatment durations and frequency, using larger sample sizes for more comprehensive insights.

References

Raja S, Carr D, Cohen M, Finnerup N, Flor H, Gibson S . The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020; 161(9):1976-1982. PMC: 7680716. DOI: 10.1097/j.pain.0000000000001939. View

Cohen S, Vase L, Hooten W . Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021; 397(10289):2082-2097. DOI: 10.1016/S0140-6736(21)00393-7. View

Glare P, Aubrey K, Myles P . Transition from acute to chronic pain after surgery. Lancet. 2019; 393(10180):1537-1546. DOI: 10.1016/S0140-6736(19)30352-6. View

Luo Y, Liu Z, Yang L, Li J, Zhang Q, Peng X . Association of body pain and chronic disease: evidence from a 7-year population-based study in China. Reg Anesth Pain Med. 2021; 46(9):745-751. DOI: 10.1136/rapm-2021-102700. View

Viderman D, Tapinova K, Aubakirova M, Abdildin Y . The Prevalence of Pain in Chronic Diseases: An Umbrella Review of Systematic Reviews. J Clin Med. 2023; 12(23). PMC: 10707436. DOI: 10.3390/jcm12237302. View

van den Beuken-van Everdingen M, Hochstenbach L, Joosten E, Tjan-Heijnen V, Janssen D . Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis. J Pain Symptom Manage. 2016; 51(6):1070-1090.e9. DOI: 10.1016/j.jpainsymman.2015.12.340. View

Zhang W, Doherty M, Peat G, Bierma-Zeinstra M, Arden N, Bresnihan B . EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2009; 69(3):483-9. DOI: 10.1136/ard.2009.113100. View

Zhang Y, Jordan J . Epidemiology of osteoarthritis. Clin Geriatr Med. 2010; 26(3):355-69. PMC: 2920533. DOI: 10.1016/j.cger.2010.03.001. View

Chang J, Rukavina K, Lawn T, Chaudhuri K . Pain in neurodegenerative diseases with atypical parkinsonism: a systematic review on prevalence, clinical presentation, and findings from experimental studies. J Integr Neurosci. 2022; 20(4):1067-1078. DOI: 10.31083/j.jin2004108. View

10.

Alemzadeh-Ansari M, Ansari-Ramandi M, Naderi N . Chronic Pain in Chronic Heart Failure: A Review Article. J Tehran Heart Cent. 2017; 12(2):49-56. PMC: 5558055. View

11.

Peng J, Hepgul N, Higginson I, Gao W . Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis. Palliat Med. 2018; 33(1):24-36. PMC: 6291907. DOI: 10.1177/0269216318807051. View

12.

Davison S, Rathwell S, Ghosh S, George C, Pfister T, Dennett L . The Prevalence and Severity of Chronic Pain in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Can J Kidney Health Dis. 2021; 8:2054358121993995. PMC: 7897838. DOI: 10.1177/2054358121993995. View

13.

Ma Q . Somato-Autonomic Reflexes of Acupuncture. Med Acupunct. 2020; 32(6):362-366. PMC: 7755849. DOI: 10.1089/acu.2020.1488. View

14.

Longhurst J . Defining meridians: a modern basis of understanding. J Acupunct Meridian Stud. 2010; 3(2):67-74. DOI: 10.1016/S2005-2901(10)60014-3. View

15.

Thompson O, Powell-Roach K, Taylor J, Terry E, Booker S . Pain catastrophizing: A patient-centered approach to assessment. Nursing. 2022; 52(4):26-30. PMC: 9106311. DOI: 10.1097/01.NURSE.0000823252.50782.45. View

16.

Schulz K, Grimes D . Blinding in randomised trials: hiding who got what. Lancet. 2002; 359(9307):696-700. DOI: 10.1016/S0140-6736(02)07816-9. View

17.

Fei Y, Cao H, Xia R, Chai Q, Liang C, Feng Y . Methodological challenges in design and conduct of randomised controlled trials in acupuncture. BMJ. 2022; 376:e064345. PMC: 8868049. DOI: 10.1136/bmj-2021-064345. View

18.

Xiang A, Cheng K, Shen X, Xu P, Liu S . The Immediate Analgesic Effect of Acupuncture for Pain: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2017; 2017:3837194. PMC: 5676441. DOI: 10.1155/2017/3837194. View

19.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

20.

Harrison J, Weber S, Jakob R, Chute C . ICD-11: an international classification of diseases for the twenty-first century. BMC Med Inform Decis Mak. 2021; 21(Suppl 6):206. PMC: 8577172. DOI: 10.1186/s12911-021-01534-6. View