Synthesis of Natural Products Using Engineered Plants and Microorganisms

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Nov 9

PMID 39519694

Authors

Yongjun Wei

Lingbo Qu

Xiaojun Ji

Affiliations

Soon will be listed here.

Abstract

Microorganisms and plants, particularly medicinal herbs, are abundant sources of diverse natural products, many of which are bioactive molecules with significant pharmaceutical or health benefits, and include artemisinin [...].

References

Caballero Cerbon D, Gebhard L, Dokuyucu R, Ertl T, Hartl S, Mazhar A . Challenges and Advances in the Bioproduction of L-Cysteine. Molecules. 2024; 29(2). PMC: 10821248. DOI: 10.3390/molecules29020486. View

Bureau J, Oliva M, Dong Y, Ignea C . Engineering yeast for the production of plant terpenoids using synthetic biology approaches. Nat Prod Rep. 2023; 40(12):1822-1848. DOI: 10.1039/d3np00005b. View

Paddon C, Keasling J . Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat Rev Microbiol. 2014; 12(5):355-67. DOI: 10.1038/nrmicro3240. View

Xu M, He Y, Xie L, Qu L, Xu G, Cui C . Research Progress on Active Ingredients and Product Development of Murray. Molecules. 2024; 29(10). PMC: 11123928. DOI: 10.3390/molecules29102269. View

Zhang X, Miao Q, Pan C, Yin J, Wang L, Qu L . Research advances in probiotic fermentation of Chinese herbal medicines. Imeta. 2024; 2(2):e93. PMC: 10989925. DOI: 10.1002/imt2.93. View

Brooks S, Alper H . Applications, challenges, and needs for employing synthetic biology beyond the lab. Nat Commun. 2021; 12(1):1390. PMC: 7925609. DOI: 10.1038/s41467-021-21740-0. View

Zhang K, Zhu Y, Song S, Bu Q, You X, Zou H . Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism. Molecules. 2024; 29(5). PMC: 10934602. DOI: 10.3390/molecules29051108. View

Sun S, Liu X, Zhao D, Zheng L, Han X, Tian Y . Discovery of the Active Compounds of the Ethyl Acetate Extract Site of (Thunb.) Blume for the Treatment of Acute Lung Injury. Molecules. 2024; 29(4). PMC: 10891587. DOI: 10.3390/molecules29040770. View

Zhao L, Zhu Y, Jia H, Han Y, Zheng X, Wang M . From Plant to Yeast-Advances in Biosynthesis of Artemisinin. Molecules. 2022; 27(20). PMC: 9609949. DOI: 10.3390/molecules27206888. View

10.

Choi K, Jang W, Yang D, Cho J, Park D, Lee S . Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering. Trends Biotechnol. 2019; 37(8):817-837. DOI: 10.1016/j.tibtech.2019.01.003. View

11.

Ma Q, Zhang S, Yang L, Xie Q, Dai H, Yu Z . Lanostane Triterpenoids and Ergostane Steroids from and Their Cytotoxicity. Molecules. 2022; 27(20). PMC: 9611895. DOI: 10.3390/molecules27206989. View

12.

Chen R, Gao J, Yu W, Chen X, Zhai X, Chen Y . Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast. Nat Chem Biol. 2022; 18(5):520-529. DOI: 10.1038/s41589-022-01014-6. View

13.

Li L, Xiong Y, Wang Y, Wu S, Xiao C, Wang S . Effect of Nano-Selenium on Nutritional Quality of Cowpea and Response of ABCC Transporter Family. Molecules. 2023; 28(3). PMC: 9921613. DOI: 10.3390/molecules28031398. View

14.

Ma J, Gu Y, Marsafari M, Xu P . Synthetic biology, systems biology, and metabolic engineering of Yarrowia lipolytica toward a sustainable biorefinery platform. J Ind Microbiol Biotechnol. 2020; 47(9-10):845-862. DOI: 10.1007/s10295-020-02290-8. View

15.

Sun T, Zhao Y, Wang J, Kang W, Sun X, Sun Y . Increasing 1,4-Diaminobutane Production in by Optimization of Cofactor PLP and NADPH Synthesis. Molecules. 2024; 29(13). PMC: 11243127. DOI: 10.3390/molecules29133094. View

16.

Alanazi A, Alqasmi M, Alrouji M, Kuriri F, Almuhanna Y, Joseph B . Antibacterial Activity of (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant . Molecules. 2022; 27(23). PMC: 9736006. DOI: 10.3390/molecules27238551. View

17.

Su J, Peng T, Bai M, Bai H, Li H, Pan H . Transcriptome and Metabolome Analyses Provide Insights into the Flavonoid Accumulation in Peels of 'Chachi'. Molecules. 2022; 27(19). PMC: 9570620. DOI: 10.3390/molecules27196476. View

18.

Tu Z, Geng A, Xiang Y, Zayas-Garriga A, Guo H, Zhu D . Lignin Degradation by TL3 under Anaerobic Conditions. Molecules. 2024; 29(10). PMC: 11124209. DOI: 10.3390/molecules29102177. View

19.

Drozdzynski P, Rutkowska N, Rodziewicz M, Marchut-Mikolajczyk O . Bioactive Compounds Produced by Endophytic Bacteria and Their Plant Hosts-An Insight into the World of Chosen Herbaceous Ruderal Plants in Central Europe. Molecules. 2024; 29(18). PMC: 11433698. DOI: 10.3390/molecules29184456. View

20.

Ro D, Paradise E, Ouellet M, Fisher K, Newman K, Ndungu J . Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature. 2006; 440(7086):940-3. DOI: 10.1038/nature04640. View