Structural and Biological Studies of Bioactive Silver(I) Complexes with Coumarin Acid Derivatives

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Nov 9

PMID 39519634

Authors

Anna Wolska

Aleksandra Drzewiecka-Antonik

Cristina Aparecida Barboza

Marta Struga

Joanna Stefanska

Pawel Rejmak

Marcin Klepka

Affiliations

Soon will be listed here.

Abstract

Two new Ag(I) complexes with coumaric carboxylic acid derivatives have been synthesized. Structural studies of these noncrystalline complexes have been performed using a methodology that combines laboratory and synchrotron techniques, supported by density functional theory calculations. The arrangement of ligands around the Ag(I) cation has been refined using infrared, extended X-ray absorption fine structure, and X-ray absorption near edge structure spectroscopies. Different coordination modes of carboxylate ligands are observed for the studied compounds. Carboxylate bridges are characteristic for the Ag(I) complex with 4-oxo-4-1-benzopyran-2-carboxylic acid (), while a bidentate chelating motif was found for the complex with 2-oxo-2-1-benzopyran-3-carboxylic acid (). Additionally, the carbonyl oxygen atom of the coumarin ring coordinates to the silver cation in complex , while it is inactive in complex . Antimicrobial evaluation has been performed for both compounds. The complexes show activity against selected bacteria as well as yeast. This activity is slightly lower for bacteria and the same or higher for in relation to the reference substances: ciprofloxacin or fluconazole.

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