The RAAS System SNPs Polymorphism is Associated with Essential Hypertension Risk in Rural Areas in Northern China

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2024 Nov 8

PMID 39512695

Authors

Jin Cheng

Jing Cui

Yuanyuan Li

Xiaona Liu

Yuting Jiang

Qiaoling Liu

Chang Liu

Hongqi Feng

Zhe Jiao

Xinhua Shao

Yanhui Gao

Dianjun Sun

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Epidemiological evidence has shown that genetics and environment are associated with the risk of hypertension. However, the specific SNP effects of a cluster of crucial genes in the RAAS system on the risk of hypertension are unclear. A case-control study was performed on the baseline participants of Environment and Chronic Disease in Rural Areas of Heilongjiang China (ECDRAHC) study. According to the inclusion and exclusion criteria, 757 subjects (428 hypertensive patients) were enrolled. A total of 32 SNP sites and related haplotypes, involved in , , , , , , , and genes which exert important roles in renin-angiotensin-aldosterone system (RAAS) system were analyzed. Furthermore, a polygenic scoring model was established to assess individual risk of developing hypertension based on the comprehensive SNPs effects in genes related the RAAS system. After controlling the impact of confounding factors, multivariate logistic regression analysis revealed that the distribution of , and was associated with susceptibility to essential hypertension. In genetic score model, the score > -0.225 had a higher risk, the ( was 1.229 (1.110, 1.362). To the best of our knowledge, this is the first time a hypertension risk scoring model on RAAS associated gene cluster has been constructed, which will provide a novel approach for prevention and control of essential hypertension.

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