Dexmedetomidine Alleviates Intestinal Ischemia/reperfusion Injury by Modulating Intestinal Neuron Autophagy and Mitochondrial Homeostasis Via Nupr1 Regulation

Overview

Journal Mol Med

Publisher Biomed Central

Specialties General Medicine
Molecular Biology

Date 2024 Nov 7

PMID 39508252

Authors

Qiong Wu

Qiuhong Chen

Sisi Liang

Jinping Nie

Yingjie Wang

Chenlu Fan

Zhen Liu

Xuekang Zhang

Affiliations

Soon will be listed here.

Abstract

Intestinal ischemia/reperfusion injury (I/R) is a common yet challenging-to-treat condition, presenting a significant clinical challenge. This study aims to investigate the protective mechanisms of Dexmedetomidine (Dex) against I/R injury, with a particular focus on its role in regulating autophagy activity in intestinal neurons and maintaining mitochondrial homeostasis. Experimental findings demonstrate that Dex can mitigate intestinal damage induced by I/R through the modulation of autophagy activity and mitochondrial function in intestinal neurons by suppressing the expression of Nupr1. This discovery sheds light on a new molecular mechanism underlying the potential efficacy of Dex in treating intestinal I/R injury, offering valuable insights for clinical therapy.

Citing Articles

ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation.

Wang G, Li W, Li Y, Ma M, Guo K Neuromolecular Med. 2025; 27(1):16.

PMID: 40009287 DOI: 10.1007/s12017-025-08841-5.

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