» Articles » PMID: 39507237

Hemodynamic Markers Independent of Pulmonary Capillary Wedge Pressure Can Discriminate Between Pre and Postcapillary Exercise-induced Pulmonary Hypertension

Overview
Journal Pulm Circ
Publisher Wiley
Specialty Pulmonary Medicine
Date 2024 Nov 7
PMID 39507237
Authors
Affiliations
Soon will be listed here.
Abstract

The discrimination between pre and postcapillary exercise-induced pulmonary hypertension relies on accurate measurement of pulmonary capillary wedge pressure, which can be unreliable. We found that exercise pulmonary artery compliance and right atrial pressure (AUC 0.88, 0.89, respectively) can differentiate subtypes of exercise-induced pulmonary hypertension in the absence of wedge pressure.

References
1.
Borlaug B, Kane G, Melenovsky V, Olson T . Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction. Eur Heart J. 2016; 37(43):3293-3302. PMC: 8483148. DOI: 10.1093/eurheartj/ehw241. View

2.
van Wezenbeek J, Kianzad A, van de Bovenkamp A, Wessels J, Mouratoglou S, Braams N . Right Ventricular and Right Atrial Function Are Less Compromised in Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction: A Comparison With Pulmonary Arterial Hypertension With Similar Pressure Overload. Circ Heart Fail. 2021; 15(2):e008726. PMC: 8843396. DOI: 10.1161/CIRCHEARTFAILURE.121.008726. View

3.
Jain C, Borlaug B . Performance and Interpretation of Invasive Hemodynamic Exercise Testing. Chest. 2020; 158(5):2119-2129. PMC: 7674988. DOI: 10.1016/j.chest.2020.05.552. View

4.
Tedford R, Hassoun P, Mathai S, Girgis R, Russell S, Thiemann D . Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation. 2011; 125(2):289-97. PMC: 3264431. DOI: 10.1161/CIRCULATIONAHA.111.051540. View

5.
Baratto C, Caravita S, Dewachter C, Faini A, Perego G, Bondue A . Right Heart Adaptation to Exercise in Pulmonary Hypertension: An Invasive Hemodynamic Study. J Card Fail. 2023; 29(9):1261-1272. DOI: 10.1016/j.cardfail.2023.04.009. View