Knee Arthroscopy in the Era of Precision Medicine: A Comprehensive Review of Tailored Approaches and Emerging Technologies

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Nov 6

PMID 39502973

Authors

Vinit Rathod

Sandeep Shrivastav

Milind R Gharpinde

Affiliations

Soon will be listed here.

Abstract

Knee arthroscopy, a minimally invasive procedure, has transformed the treatment of knee pathologies by enabling direct visualization and management with minimal tissue disruption. Recent advances in precision medicine have introduced a new dimension to this field, allowing for highly individualized surgical approaches considering each patient's unique genetic, environmental, and biomechanical characteristics. This review explores the integration of precision medicine into knee arthroscopy, focusing on tailored approaches and emerging technologies. Key innovations such as robotic-assisted surgery, advanced imaging, and patient-specific instrumentation have enhanced surgical accuracy and patient outcomes, reduced recovery times, and minimized postoperative complications. The review also examines the role of biomarkers in guiding personalized treatment strategies, including ligament reconstructions, meniscal repairs, and cartilage restoration, which are now being refined to cater to the specific needs of individual patients. While the benefits of these innovations are clear, there are challenges to widespread adoption, including cost, resource allocation, and the need for further research to validate the efficacy of precision-driven approaches in knee arthroscopy. Moreover, the ethical considerations surrounding personalized medicine, such as patient privacy and genetic data usage, must also be addressed. Despite these barriers, the future of knee arthroscopy in the era of precision medicine holds great promise, with ongoing developments in artificial intelligence, genomics, and biomarker discovery poised to further refine patient-centered care. This comprehensive review provides valuable insights into how precision medicine reshapes knee arthroscopy, offering a glimpse into the future of more targeted and effective orthopedic interventions. By embracing these advancements, surgeons and healthcare providers can ensure optimal outcomes for patients undergoing knee arthroscopy.

References

Zain Z, Almadhoun M, Alsadoun L, Bokhari S . Leveraging Artificial Intelligence and Machine Learning to Optimize Enhanced Recovery After Surgery (ERAS) Protocols. Cureus. 2024; 16(3):e56668. PMC: 11032416. DOI: 10.7759/cureus.56668. View

Kluyskens L, Debieux P, Wong K, Krych A, Saris D . Biomaterials for meniscus and cartilage in knee surgery: state of the art. J ISAKOS. 2022; 7(2):67-77. DOI: 10.1136/jisakos-2020-000600. View

Stocco E, Porzionato A, De Rose E, Barbon S, De Caro R, Macchi V . Meniscus regeneration by 3D printing technologies: Current advances and future perspectives. J Tissue Eng. 2022; 13:20417314211065860. PMC: 8793124. DOI: 10.1177/20417314211065860. View

De Fazio R, Mastronardi V, De Vittorio M, Visconti P . Wearable Sensors and Smart Devices to Monitor Rehabilitation Parameters and Sports Performance: An Overview. Sensors (Basel). 2023; 23(4). PMC: 9965388. DOI: 10.3390/s23041856. View

Nunna Jr B, Parihar P, Wanjari M, Shetty N, Bora N . High-Resolution Imaging Insights into Shoulder Joint Pain: A Comprehensive Review of Ultrasound and Magnetic Resonance Imaging (MRI). Cureus. 2023; 15(11):e48974. PMC: 10725840. DOI: 10.7759/cureus.48974. View

Strianese O, Rizzo F, Ciccarelli M, Galasso G, DAgostino Y, Salvati A . Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease. Genes (Basel). 2020; 11(7). PMC: 7397223. DOI: 10.3390/genes11070747. View

Jette D, Hunter S, Burkett L, Langham B, Logerstedt D, Piuzzi N . Physical Therapist Management of Total Knee Arthroplasty. Phys Ther. 2020; 100(9):1603-1631. PMC: 7462050. DOI: 10.1093/ptj/pzaa099. View

Aderinto N, Olatunji G, Kokori E, Olaniyi P, Isarinade T, Yusuf I . Recent advances in bariatric surgery: a narrative review of weight loss procedures. Ann Med Surg (Lond). 2023; 85(12):6091-6104. PMC: 10718334. DOI: 10.1097/MS9.0000000000001472. View

Hassan A, Biaggi-Ondina A, Rajesh A, Asaad M, Nelson J, Coert J . Predicting Patient-Reported Outcomes Following Surgery Using Machine Learning. Am Surg. 2022; 89(1):31-35. PMC: 9759616. DOI: 10.1177/00031348221109478. View

10.

Poggi A, Reale D, Boffa A, Andriolo L, Di Martino A, Filardo G . Meniscus treatment: biological augmentation strategies: a narrative review. Ann Jt. 2024; 7:25. PMC: 10929437. DOI: 10.21037/aoj-21-14. View

11.

Ciliberti F, Guerrini L, Gunnarsson A, Recenti M, Jacob D, Cangiano V . CT- and MRI-Based 3D Reconstruction of Knee Joint to Assess Cartilage and Bone. Diagnostics (Basel). 2022; 12(2). PMC: 8870751. DOI: 10.3390/diagnostics12020279. View

12.

Marques L, Costa B, Pereira M, Silva A, Santos J, Saldanha L . Advancing Precision Medicine: A Review of Innovative In Silico Approaches for Drug Development, Clinical Pharmacology and Personalized Healthcare. Pharmaceutics. 2024; 16(3). PMC: 10975777. DOI: 10.3390/pharmaceutics16030332. View

13.

Wang Z, Le H, Wang Y, Liu H, Li Z, Yang X . Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions. Bioact Mater. 2022; 11:317-338. PMC: 8671106. DOI: 10.1016/j.bioactmat.2021.10.002. View

14.

Bosco F, Giustra F, Ghirri A, Cacciola G, Masse A, Capella M . All-Inside Anterior Cruciate Ligament Reconstruction Technique: Tips and Tricks. J Clin Med. 2023; 12(18). PMC: 10532376. DOI: 10.3390/jcm12185793. View

15.

Lee Y, Cho D, Kim K . Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article. Neurospine. 2024; 21(1):8-17. PMC: 10992634. DOI: 10.14245/ns.2347184.592. View

16.

Awad H, Ahmed A, Urman R, Stoicea N, Bergese S . Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery. Pharmgenomics Pers Med. 2019; 12:145-154. PMC: 6666379. DOI: 10.2147/PGPM.S198224. View

17.

Chen Q, Chen E, Qian X . A Narrative Review on Perioperative Pain Management Strategies in Enhanced Recovery Pathways-The Past, Present and Future. J Clin Med. 2021; 10(12). PMC: 8229260. DOI: 10.3390/jcm10122568. View

18.

Furman A, Hsu W . Augmented Reality (AR) in Orthopedics: Current Applications and Future Directions. Curr Rev Musculoskelet Med. 2021; 14(6):397-405. PMC: 8733124. DOI: 10.1007/s12178-021-09728-1. View

19.

Abyzova E, Dogadina E, Rodriguez R, Petrov I, Kolesnikova Y, Zhou M . Beyond Tissue replacement: The Emerging role of smart implants in healthcare. Mater Today Bio. 2023; 22:100784. PMC: 10507164. DOI: 10.1016/j.mtbio.2023.100784. View

20.

Gawande V, Badge A . Clinical Effectiveness of Arthroscopy-Assisted Fixation in the Treatment of Avulsed Posterior Cruciate Ligament Injuries. Cureus. 2024; 15(12):e50152. PMC: 10771625. DOI: 10.7759/cureus.50152. View