Gut Microbiota and Parkinson's Disease

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2024 Nov 6

PMID 39501822

Authors

Lin Wang

Ying Cui

Bingyu Han

Yitong Du

Kenish Sirajbhai Salewala

Shiya Wang

Wenlu Zhao

Hongxin Zhang

Sichen Wang

Xinran Xu

Jianpeng Ma

Yan Zhu

Houzhen Tuo

Affiliations

Soon will be listed here.

Abstract

Emerging evidence suggests that dysbiosis of the gut microbiota is associated with the pathogenesis of Parkinson's disease (PD), a prevalent neurodegenerative disorder. The microbiota-gut-brain axis plays a crucial role in the development and progression of PD, and numerous studies have demonstrated the potential therapeutic benefits of modulations in the intestinal microbiota. This review provides insights into the characterization of the gut microbiota in patients with PD and highlights associations with clinical symptoms and underlying mechanisms. The discussion underscores the increased influence of the gut microbiota in the pathogenesis of PD. While the relationship is not fully elucidated, existing research demonstrates a strong correlation between changes in the composition of gut microbiota and disease development, and further investigation is warranted to explain the specific underlying mechanisms.

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